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In Situ Transformation of Chitosan Films into Microtubular Structures on the Surface of Nanoengineered Titanium Implants

Gulati, Karan ; Johnson, Lucas ; Karunagaran, Ramesh ; Findlay, David ; Losic, Dusan

Biomacromolecules, 2016-04, Vol.17 (4), p.1261-1271 [Periódico revisado por pares]

United States: American Chemical Society

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Título:
In Situ Transformation of Chitosan Films into Microtubular Structures on the Surface of Nanoengineered Titanium Implants
Autor: Gulati, Karan ; Johnson, Lucas ; Karunagaran, Ramesh ; Findlay, David ; Losic, Dusan
Assuntos: Biocompatible Materials - chemical synthesis ; Biocompatible Materials - chemistry ; Bone Regeneration ; Chitosan - chemistry ; Coated Materials, Biocompatible - chemistry ; Drug Delivery Systems - methods ; Ferric Compounds - chemistry ; Humans ; Metal Nanoparticles - chemistry ; Polymers - chemical synthesis ; Polymers - chemistry ; Prostheses and Implants ; Surface Properties ; Tissue Engineering - methods ; Titanium - chemistry
É parte de: Biomacromolecules, 2016-04, Vol.17 (4), p.1261-1271
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: There is considerable interest in combining bioactive polymers such as chitosan with titanium bone implants to promote bone healing and address therapeutic needs. However, the fate of these biodegradable polymers especially on titanium implants is not fully explored. Here we report in situ formation of chitosan microtube (CMT) structures from chitosan films on the implant surface with titania nanotubes (TNTs) layer, based on phosphate buffer-induced transformation and precipitation process. We have comprehensively analyzed this phenomenon and the factors that influence CMT formation, including substrate topography, immersion solution and its pH, effect of coating thickness, and time of immersion. Significance of reported in situ formation of chitosan microtubes on the TNTs surface is possibly to tailor properties of implants with favorable micro and nano morphology using a self-ordering process after the implant’s insertion.
Editor: United States: American Chemical Society
Idioma: Inglês

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In Situ Transformation of Chitosan Films into Microtubular Structures on the Surface of Nanoengineered Titanium Implants

Gulati, Karan ; Johnson, Lucas ; Karunagaran, Ramesh ; Findlay, David ; Losic, Dusan

United States: American Chemical Society

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