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Abuse of androgenic anabolic drugs with “Cycling” induces hepatic steatosis in adult male mice

Kahal, Aida ; Allem, Rachida ; Zahzeh, Touria ; Oulmane, Saida ; Tafroukhte, Zahra

Steroids, 2020-03, Vol.155, p.108574, Article 108574 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Abuse of androgenic anabolic drugs with “Cycling” induces hepatic steatosis in adult male mice
Autor: Kahal, Aida ; Allem, Rachida ; Zahzeh, Touria ; Oulmane, Saida ; Tafroukhte, Zahra
Assuntos: Alanine Transaminase - blood ; Anabolic Agents - administration & dosage ; Anabolic Agents - adverse effects ; Androgenic drugs ; Androgens - administration & dosage ; Androgens - adverse effects ; Animals ; Aspartate Aminotransferases - blood ; Cycling ; Cyto-architecture ; Disease Models, Animal ; Doping ; Fatty Liver - chemically induced ; Fatty Liver - metabolism ; Liver ; Male ; Mice ; Nandrolone Decanoate - administration & dosage ; Nandrolone Decanoate - adverse effects ; Substance Abuse Detection
É parte de: Steroids, 2020-03, Vol.155, p.108574, Article 108574
Descrição: •This study tested the usefulness of the “Cycling” protocol in the SAA abuse.•The protocol is simplified to better follow the liver response at stop treatment.•Stop treatment showed a very distinguished periportal microvesicular steatosis.•Then, “Cycling” leads to the accumulation of fat in the liver.•And increases hepatic distress. The importance of the present study comes from the lack of sufficient information about the reversibility of the potential hepatic histopathological alterations which may result from anabolic androgenic drugs abuse by “Cycling” protocol. So, the aim of this study is to explore the negative effects of Deca-Durabolin abuse in hepatic function and structure during an administration cycle. For our purpose, study was performed on 40 male adult mices. Animals were divided into five groups of 8 animals each treated weekly by Deca-Durabolin (nandrolone decanoate) at 30 g/kg of BW during one month (GI); during two months (GII); during three months (GIII); during three months followed by six weeks of treatment discontinuation (GIV) and Control (C). Plasma assay of liver enzymes (ALT and AST) and cytohistological examination to determine the histopathological damage properties of the liver were performed. Our results showed that the animals supported very well the administrated substance. Our study showed an increase in plasma levels of liver enzymes (ALT and AST) with the duration of treatment accompanied by important degenerative changes in hepatic tissue with peliosis evolution after two months of treatment. These damages worsen again 6 weeks after stopping treatment and ended by the development of hepatic steatosis with increases hepatic distress. These results ported that the use of AAS with “Cycling” may lead to the development of hepatic steatosis before progressing to more serious pathological liver situations in AAS abusers.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Abuse of androgenic anabolic drugs with “Cycling” induces hepatic steatosis in adult male mice

Kahal, Aida ; Allem, Rachida ; Zahzeh, Touria ; Oulmane, Saida ; Tafroukhte, Zahra

United States: Elsevier Inc

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