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The feet in systemic lupus erythematosus; are we underestimating their involvement and functional impact?

Morales-Lozano, Rosario ; Martínez-Barrio, Julia ; González-Fernández, María Luz ; López-Longo, Francisco Javier ; Ovalles-Bonilla, Juan Gabriel ; Valor, Lara ; Janta, Iustina ; Nieto, Juan Carlos ; Hernández-Flórez, Diana ; González, Carlos M ; Monteagudo, Indalecio ; Garrido, Jesús ; Carreño, Luis ; Naredo, Esperanza

Clinical and experimental rheumatology, 2016-07, Vol.34 (4), p.609-617 [Periódico revisado por pares]

Italy

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Título:
The feet in systemic lupus erythematosus; are we underestimating their involvement and functional impact?
Autor: Morales-Lozano, Rosario ; Martínez-Barrio, Julia ; González-Fernández, María Luz ; López-Longo, Francisco Javier ; Ovalles-Bonilla, Juan Gabriel ; Valor, Lara ; Janta, Iustina ; Nieto, Juan Carlos ; Hernández-Flórez, Diana ; González, Carlos M ; Monteagudo, Indalecio ; Garrido, Jesús ; Carreño, Luis ; Naredo, Esperanza
Assuntos: Autoantibodies - blood ; Biomarkers - blood ; Biomechanical Phenomena ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Foot - diagnostic imaging ; Foot - physiopathology ; Foot Deformities, Acquired - blood ; Foot Deformities, Acquired - diagnostic imaging ; Foot Deformities, Acquired - etiology ; Foot Deformities, Acquired - physiopathology ; Humans ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - diagnosis ; Pain - blood ; Pain - diagnostic imaging ; Pain - etiology ; Pain - physiopathology ; Pain Measurement ; Podiatry - methods ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Severity of Illness Index ; Ultrasonography, Doppler
É parte de: Clinical and experimental rheumatology, 2016-07, Vol.34 (4), p.609-617
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: To evaluate biomechanical and ultrasound (US) abnormalities in SLE patients as compared with controls and to assess the relationship between these abnormalities and SLE activity. Fifty-four consecutive female patients with SLE with and without foot pain and 60 female controls (30 with foot pain and 30 without foot pain) were recruited. SLE activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). SLE patients and controls blindly underwent a comprehensive podiatric, biomechanical and US evaluation of the feet. US assessment included detection of B-mode synovitis, tenosynovitis, enthesopathy, bone changes and synovial, tenosynovial and entheseal power Doppler (PD) signal. Thirty-one (57.4%) SLE patients had bilateral foot pain and 5 (9.3%) had unilateral foot pain. Metatarsalgia was the most common location for pain but without significant difference between groups (p=0.284). Toe joint deformities were significantly more common in SLE feet as compared with control feet (p<0.0005). SLE feet showed significantly more biomechanical abnormalities than control feet (p<0.05). B-mode synovitis in the tibiotalar joint was strongly associated with having SLE (p<0.0005) and the presence of synovial PD signal in the MTP joints was found only in painful feet of SLE patients. SLEDAI was significantly higher in patients with foot pain than in those with painless feet (p=0.008). However, SLEDAI did not discriminate between patients with and without biomechanical or US abnormalities. SLE patients showed more biomechanical and US abnormalities in the feet than controls, which were not captured by standardised assessment of the disease activity.
Editor: Italy
Idioma: Inglês

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The feet in systemic lupus erythematosus; are we underestimating their involvement and functional impact?

Italy

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