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Thalidomide-associated hypothyroidism in a patient with multiple myeloma

Okamura, Ikue ; Ikeda, Takashi ; Sato, Ken ; Kimura, Fumihiko

Rinshō ketsueki, 2015-01, Vol.56 (1), p.38

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Título:
Thalidomide-associated hypothyroidism in a patient with multiple myeloma
Autor: Okamura, Ikue ; Ikeda, Takashi ; Sato, Ken ; Kimura, Fumihiko
Assuntos: Aged ; Constipation - chemically induced ; Humans ; Hypothyroidism - chemically induced ; Hypothyroidism - diagnosis ; Male ; Multiple Myeloma - drug therapy ; Thalidomide - administration & dosage ; Thalidomide - adverse effects ; Thalidomide - analogs & derivatives ; Thalidomide - therapeutic use ; Thyroid Function Tests - methods
É parte de: Rinshō ketsueki, 2015-01, Vol.56 (1), p.38
Descrição: Thalidomide is highly effective against multiple myeloma, but some patients must discontinue this medication due to adverse effects. We present herein an instructive case report on thalidomide-associated hypothyroidism in a patient with multiple myeloma. Thyroid hormone replacement therapy allowed us to restart administration of thalidomide, a potentially life-saving therapy. Known adverse effects of thalidomide, such as lethargy, constipation, and bradycardia, are potential symptoms of hypothyroidism, but we tend to overlook drug-associated hypothyroidism. Our case highlights the importance of routinely testing thyroid function in patients receiving thalidomide therapy.
Editor: Japan
Idioma: Japonês

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