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Increased lung cancer mortality among chrysotile asbestos textile workers is more strongly associated with exposure to long thin fibres

Loomis, Dana ; Dement, John M ; Elliott, Leslie ; Richardson, David ; Kuempel, Eileen D ; Stayner, Leslie

Occupational and environmental medicine (London, England), 2012-08, Vol.69 (8), p.564-568 [Periódico revisado por pares]

London: BMJ Publishing Group Ltd

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Título:
Increased lung cancer mortality among chrysotile asbestos textile workers is more strongly associated with exposure to long thin fibres
Autor: Loomis, Dana ; Dement, John M ; Elliott, Leslie ; Richardson, David ; Kuempel, Eileen D ; Stayner, Leslie
Assuntos: Asbestos ; Asbestos, Serpentine - adverse effects ; Asbestos, Serpentine - analysis ; asthma ; Biological and medical sciences ; Cancer ; Carcinogens, Environmental - adverse effects ; Carcinogens, Environmental - analysis ; chrysotile ; Correlations ; Dose response relationship ; Dust - analysis ; Epidemiology ; Estimation methods ; Exposure ; Female ; Fibers ; Fibres ; Humans ; hygiene/occupational hygiene ; lung cancer ; Lung neoplasms ; Lung Neoplasms - etiology ; Lung Neoplasms - mortality ; Lungs ; Male ; Medical sciences ; Modeling ; Mortality ; North Carolina - epidemiology ; Occupational Diseases - etiology ; Occupational Diseases - mortality ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Occupations ; Particle Size ; Particulate Matter - adverse effects ; Pneumology ; Poisson Distribution ; Public health ; respiratory ; Risk ; Risk Factors ; South Carolina - epidemiology ; Textile Industry ; Textiles ; Tumors of the respiratory system and mediastinum ; Work ; Workplace
É parte de: Occupational and environmental medicine (London, England), 2012-08, Vol.69 (8), p.564-568
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Descrição: BackgroundAnimal data and physical models suggest that the carcinogenicity of asbestos fibres is related to their size and shape.ObjectivesTo investigate the influence of fibre length and diameter on lung cancer risk in workers at asbestos textile mills in North Carolina and South Carolina, USA.MethodsMen and women (n=6136) who worked ≥30 days in production and were employed between 1940 and 1973 were enumerated and followed for vital status through 2003. A matrix of fibre size-specific exposure estimates was constructed using determinations of fibre numbers and dimensions through analysis of 160 historical dust samples by transmission electron microscopy. Associations of lung cancer mortality with metrics of fibre exposure were estimated by Poisson regression with adjustment for age, sex, race and calendar year.ResultsExposure to fibres throughout the range of length and diameter was significantly associated with increased risk of lung cancer. Models for fibres >5 μm long and <0.25 μm in diameter provided the best fit to the data, while fibres 5–10 μm long and <0.25 μm in diameter were associated most strongly with lung cancer mortality (log rate about 4% per IQR, p<0.001). When indicators of mean fibre length and diameter were modelled simultaneously, lung cancer risk increased as fibre length increased and diameter decreased.ConclusionsThe findings support the hypothesis that the occurrence of lung cancer is associated most strongly with exposure to long thin asbestos fibres. The relationship of cancer risk and fibre dimensions should be examined in cohorts exposed to other types of fibres.
Editor: London: BMJ Publishing Group Ltd
Idioma: Inglês

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Increased lung cancer mortality among chrysotile asbestos textile workers is more strongly associated with exposure to long thin fibres

Loomis, Dana ; Dement, John M ; Elliott, Leslie ; Richardson, David ; Kuempel, Eileen D ; Stayner, Leslie

London: BMJ Publishing Group Ltd

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