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Spontaneous Resolution of Genital Chlamydia trachomatis Infection in Women and Protection from Reinfection

Geisler, William M. ; Lensing, Shelly Y. ; Press, Christen G. ; Hook, Edward W.

The Journal of infectious diseases, 2013-06, Vol.207 (12), p.1850-1856 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Spontaneous Resolution of Genital Chlamydia trachomatis Infection in Women and Protection from Reinfection
Autor: Geisler, William M. ; Lensing, Shelly Y. ; Press, Christen G. ; Hook, Edward W.
Assuntos: Adolescent ; Adult ; Anti-Bacterial Agents - therapeutic use ; Azithromycin - therapeutic use ; BACTERIA ; Bacteriology ; Biological and medical sciences ; Chlamydia ; Chlamydia Infections - drug therapy ; Chlamydia Infections - immunology ; Chlamydia Infections - microbiology ; Chlamydia Infections - prevention & control ; Chlamydia trachomatis ; Chlamydia trachomatis - physiology ; Cohort Studies ; Disease risks ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Genital Diseases, Female - drug therapy ; Genital Diseases, Female - immunology ; Genital Diseases, Female - microbiology ; Genital Diseases, Female - prevention & control ; Genitalia ; Humans ; Immunity ; Infections ; Infectious diseases ; Major and Brief Reports ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Natural history ; Prospective Studies ; Reinfection ; Remission, Spontaneous ; Risk Factors ; Screening tests ; Secondary Prevention ; Sexually transmitted diseases ; Young Adult
É parte de: The Journal of infectious diseases, 2013-06, Vol.207 (12), p.1850-1856
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Descrição: The natural history of chlamydia is variable and may include persisting asymptomatic infection, complications, or spontaneous resolution before treatment. Reinfection is common. We evaluated whether spontaneous resolution was associated with decreased reinfection in women returning for treatment of a positive chlamydia screening test. At enrollment, participants were tested for chlamydia, treated with azithromycin, and scheduled for a 6-month follow-up visit for repeat testing. Two hundred participants returned 1 to 12 months after treatment. Spontaneous resolution at enrollment was demonstrated in 44 (22.0%). Reinfection at follow-up occurred in 33 (16.5%), being more frequent in those with persisting infection at enrollment versus spontaneous resolution (31 of 156 [19.9%] vs 2 of 44 [4.5%]; P = .016). Adjusting for age, the odds of reinfection was 4 times higher for participants with persisting infection at enrollment (odds ratio 4.0, 95% confidence interval, 1.1—25.6; P = .034). Chlamydia treatment may attenuate protective immunity in some patients.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Spontaneous Resolution of Genital Chlamydia trachomatis Infection in Women and Protection from Reinfection

Geisler, William M. ; Lensing, Shelly Y. ; Press, Christen G. ; Hook, Edward W.

Oxford: Oxford University Press

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