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Antioxidant and Anti-inflammatory Phenylpropanoid Derivatives from Calamus quiquesetinervius

Chang, Chao-Lin ; Zhang, Li-Jie ; Chen, Ru Yin ; Kuo, Li-Ming Yang ; Huang, Jhih-Ping ; Huang, Hui-Chi ; Lee, Kuo-Hsiung ; Wu, Yang-Chang ; Kuo, Yao-Haur

Journal of natural products (Washington, D.C.), 2010-09, Vol.73 (9), p.1482-1488 [Periódico revisado por pares]

Northbrook, IL: American Chemical Society and American Society of Pharmacognosy

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Título:
Antioxidant and Anti-inflammatory Phenylpropanoid Derivatives from Calamus quiquesetinervius
Autor: Chang, Chao-Lin ; Zhang, Li-Jie ; Chen, Ru Yin ; Kuo, Li-Ming Yang ; Huang, Jhih-Ping ; Huang, Hui-Chi ; Lee, Kuo-Hsiung ; Wu, Yang-Chang ; Kuo, Yao-Haur
Assuntos: Animals ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Biological and medical sciences ; Biphenyl Compounds - pharmacology ; Calamus - chemistry ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - isolation & purification ; Drugs, Chinese Herbal - pharmacology ; Free Radical Scavengers - chemistry ; Free Radical Scavengers - isolation & purification ; Free Radical Scavengers - pharmacology ; General pharmacology ; Glycosides - chemistry ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Lipopolysaccharides - pharmacology ; Macrophages - drug effects ; Medical sciences ; Mice ; Molecular Structure ; Nitric Oxide - biosynthesis ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenylpropionates - chemistry ; Phenylpropionates - isolation & purification ; Phenylpropionates - pharmacology ; Picrates - pharmacology ; Plant Stems - chemistry ; Quercetin - pharmacology ; Taiwan
É parte de: Journal of natural products (Washington, D.C.), 2010-09, Vol.73 (9), p.1482-1488
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Eight new phenylpropanoid derivatives [quiquesetinerviusides A (1), B (2), C (3), D (4), and E (5), as well as quiquesetinerviusins A (6), B (7), and C (8)] and seven known compounds (8−15), were isolated from an EtOAc extract of Calamus quiquesetinervius stems. The structures of 1−8 were elucidated on the basis of 1D- and 2D-NMR spectroscopic data analysis. Bioassay results showed that 1−5 possess weak DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, but potent · OH radical scavenging activity (IC50 3.6−8.4 μM). Of the tested isolates, compounds 4−6 and 9 showed potent inhibition (IC50 9.2−29.5 μM) of LPS-stimulated NO production when compared with a positive control substance, quercetin (IC50 34.5 μM).
Editor: Northbrook, IL: American Chemical Society and American Society of Pharmacognosy
Idioma: Inglês

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Antioxidant and Anti-inflammatory Phenylpropanoid Derivatives from Calamus quiquesetinervius

Chang, Chao-Lin ; Zhang, Li-Jie ; Chen, Ru Yin ; Kuo, Li-Ming Yang ; Huang, Jhih-Ping ; Huang, Hui-Chi ; Lee, Kuo-Hsiung ; Wu, Yang-Chang ; Kuo, Yao-Haur

Northbrook, IL: American Chemical Society and American Society of Pharmacognosy

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