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Therapeutic oligonucleotides methods and protocols

John Goodchild chemist

New York Humana Press Springer c2011

Localização: CQ - Conjunto das Químicas    (615.31 T398 )(Acessar)

  • Título:
    Therapeutic oligonucleotides methods and protocols
  • Autor: John Goodchild chemist
  • Assuntos: Oligonucleotides -- Therapeutic use; Oligonucleotides -- therapeutic use; OLIGONUCLEOTÍDEOS; GENÉTICA MOLECULAR; FARMACOLOGIA
  • Notas: Includes bibliographical references and index
  • Descrição: Therapeutic oligonucleotides / Dinucleotides containing 3-S-phosphorothiolate linkages / 2-O,4-C-methyleneoxymethylene bridged nucleic acids (2,4-BNACOC) / Non-covalent peptide-based strategy for ex vivo and in vivo oligonucleotide delivery / Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides / Nanoparticle for tumor targeted delivery of oligomers / Light-directed delivery of nucleic acids / Antibody targeted siRNA delivery / Aptamer-drug conjugation for targeted tumor cell therapy / Five-step process for screening antisense compounds for efficacy: gene target IL-12Rb2 / Diverse small non-coding RNAs in RNA interference pathways / Quantification of siRNAs in vitro and in vivo / Optimization of transfection conditions and analysis of siRNA potency using real-time PCR / siRNA knockdown of gene expression in endothelial cells / Using RNA interference in Schistosoma mansoni / Performing the labeled microRNA pull-down (LAMP) assay system : an experimental approach for high-throughput identification of microRNA-target mRNAs / Synthesis, purification, and characterization of oligoribonucleotides that act as agonists of TLR7 and/or TLR8 /
    Synthesis, purification, and characterization of immune-modulatory oligodeoxynucleotides that act as agonists of toll-like receptor 9 Surface plasmon resonance investigation of RNA aptamer-RNA ligand interactions / Practical considerations for analyzing antigene RNAs (agRNAs) : RNA immunoprecipitation of argonaute protein / Inhibition of human papillomavirus expression using DNAzymes /
  • Títulos relacionados: Série:Methods in molecular biology (Clifton, N.J.) v. 764; Springer protocols
  • Editor: New York Humana Press Springer
  • Data de criação/publicação: c2011
  • Formato: xi, 340 p ill 27 cm.
  • Idioma: Inglês

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