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Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope

Liu, XF ; Onda, M ; Schlomer, J ; Bassel, L ; Kozlov, S ; Tai, C-H ; Zhou, Q ; Liu, W ; Tsao, H-E ; Hassan, R ; Ho, M ; Pastan, I

Proceedings of the National Academy of Sciences of the United States of America, 2024-01, Vol.121 (4)

eScholarship, University of California

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Título:
Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope
Autor: Liu, XF ; Onda, M ; Schlomer, J ; Bassel, L ; Kozlov, S ; Tai, C-H ; Zhou, Q ; Liu, W ; Tsao, H-E ; Hassan, R ; Ho, M ; Pastan, I
Assuntos: 2.2 Factors relating to the physical environment ; 5.1 Pharmaceuticals ; Aetiology ; antibody ; Bacteria ; Bacterial ; Bacterial Proteins ; Biological Sciences ; Biomedical and Clinical Sciences ; Biotechnology ; Cancer ; Cell Line ; Chimeric Antigen ; Development of treatments and therapeutic interventions ; Digestive Diseases ; Female ; Fimbriae ; Flagella ; flagellar motor ; GPI-Linked Proteins ; Humans ; Immunology ; immunotherapy ; Infection ; Infectious Diseases ; Lung ; Lung Cancer ; mechanoresponse ; Mesothelin ; Microbiology ; nanomachine ; Oncology and Carcinogenesis ; Orphan Drug ; ovarian cancer ; Pancreatic Cancer ; Pancreatic Neoplasms ; Rare Diseases ; Receptors ; T-Lymphocytes ; Tumor
É parte de: Proceedings of the National Academy of Sciences of the United States of America, 2024-01, Vol.121 (4)
Notas: Proceedings of the National Academy of Sciences of the United States of America, vol 121, iss 4
e2317283121
Descrição: Bacterial flagella and type IV pili (TFP) are surface appendages that enable motility and mechanosensing through distinct mechanisms. These structures were previously thought to have no components in common. Here, we report that TFP and some flagella share proteins PilO, PilN, and PilM, which we identified as part of the Helicobacter pylori flagellar motor. H. pylori mutants lacking PilO or PilN migrated better than wild type in semisolid agar because they continued swimming rather than aggregated into microcolonies, mimicking the TFP-regulated surface response. Like their TFP homologs, flagellar PilO/PilN heterodimers formed a peripheral cage that encircled the flagellar motor. These results indicate that PilO and PilN act similarly in flagella and TFP by differentially regulating motility and microcolony formation when bacteria encounter surfaces.
Editor: eScholarship, University of California
Idioma: Inglês

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Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope

Liu, XF ; Onda, M ; Schlomer, J ; Bassel, L ; Kozlov, S ; Tai, C-H ; Zhou, Q ; Liu, W ; Tsao, H-E ; Hassan, R ; Ho, M ; Pastan, I

eScholarship, University of California

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