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A novel potent tumour promoter aberrantly overexpressed in most human cancers

Takahashi, Atsushi ; Tokita, Hisashi ; Takahashi, Kenzo ; Takeoka, Tomoharu ; Murayama, Kosho ; Tomotsune, Daihachiro ; Ohira, Miki ; Iwamatsu, Akihiro ; Ohara, Kazuaki ; Yazaki, Kazufumi ; Koda, Tadayuki ; Nakagawara, Akira ; Tani, Kenzaburo

Scientific reports, 2011-06, Vol.1 (1), p.15, Article 15 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
A novel potent tumour promoter aberrantly overexpressed in most human cancers
Autor: Takahashi, Atsushi ; Tokita, Hisashi ; Takahashi, Kenzo ; Takeoka, Tomoharu ; Murayama, Kosho ; Tomotsune, Daihachiro ; Ohira, Miki ; Iwamatsu, Akihiro ; Ohara, Kazuaki ; Yazaki, Kazufumi ; Koda, Tadayuki ; Nakagawara, Akira ; Tani, Kenzaburo
Assuntos: Animal models ; Animals ; Cancer screening ; Cell Line, Tumor ; Cell Transformation, Neoplastic - genetics ; Gene expression ; Gene Expression Regulation, Neoplastic - genetics ; Genetic Predisposition to Disease - genetics ; Hedgehog protein ; Hepatocellular carcinoma ; Humans ; Invasiveness ; Kinases ; Liver cancer ; Lung cancer ; Lymphoma ; Medical screening ; Methyltransferases - genetics ; Mice ; Mice, Transgenic ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; Neoplasms - genetics ; Promoter Regions, Genetic - genetics ; Protein-tyrosine kinase ; Protein-tyrosine kinase receptors ; Rodents ; Signal transduction ; Spleen ; Thymus ; Transgenic mice ; Tumorigenesis ; Tumors ; Tyrosine ; Up-Regulation
É parte de: Scientific reports, 2011-06, Vol.1 (1), p.15, Article 15
Descrição: The complexity and heterogeneity of tumours have hindered efforts to identify commonalities among different cancers. Furthermore, because we have limited information on the prevalence and nature of ubiquitous molecular events that occur in neoplasms, it is unfeasible to implement molecular-targeted cancer screening and prevention. Here, we found that the FEAT protein is overexpressed in most human cancers, but weakly expressed in normal tissues including the testis, brain, and liver. Transgenic mice that ectopically expressed FEAT in the thymus, spleen, liver, and lung spontaneously developed invasive malignant lymphoma (48%, 19/40) and lung-metastasizing liver cancer (hepatocellular carcinoma) (35%, 14/40) that models human hepatocarcinogenesis, indicating the FEAT protein potently drives tumorigenesis in vivo. Gene expression profiling suggested that FEAT drives receptor tyrosine kinase and hedgehog signalling pathways. These findings demonstrate that integrated efforts to identify FEAT-like ubiquitous oncoproteins are useful and may provide promising approaches for cost-effective cancer screening and prevention.
Editor: England: Nature Publishing Group
Idioma: Inglês

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A novel potent tumour promoter aberrantly overexpressed in most human cancers

Takahashi, Atsushi ; Tokita, Hisashi ; Takahashi, Kenzo ; Takeoka, Tomoharu ; Murayama, Kosho ; Tomotsune, Daihachiro ; Ohira, Miki ; Iwamatsu, Akihiro ; Ohara, Kazuaki ; Yazaki, Kazufumi ; Koda, Tadayuki ; Nakagawara, Akira ; Tani, Kenzaburo

England: Nature Publishing Group

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