Idioma:

Antimicrobial Activities and Mechanisms of Carbapenem Resistance in Clinical Isolates of Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp

SUGINO, Yasuteru ; IINUMA, Yoshitsugu ; NADA, Toshi ; TAWADA, Yukio ; AMANO, Hiroshi ; NAKAMURA, Tadahiro ; HASEGAWA, Yoshinori ; SHIMOKATA, Kaoru ; SHIBATA, Naohiro ; ARAKAWA, Yoshichika

Kansenshogaku Zasshi, 2001/08/20, Vol.75(8), pp.662-670

Japan: The Japanese Association for Infectious Diseases

Texto completo disponível

Citações Citado por

Enviar para

Título:
Antimicrobial Activities and Mechanisms of Carbapenem Resistance in Clinical Isolates of Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp
Autor: SUGINO, Yasuteru ; IINUMA, Yoshitsugu ; NADA, Toshi ; TAWADA, Yukio ; AMANO, Hiroshi ; NAKAMURA, Tadahiro ; HASEGAWA, Yoshinori ; SHIMOKATA, Kaoru ; SHIBATA, Naohiro ; ARAKAWA, Yoshichika
Assuntos: Acinetobacter - drug effects ; Acinetobacter - enzymology ; Acinetobacter - isolation & purification ; Acinetobacter spp ; antimicrobial activity ; beta-Lactam Resistance ; beta-Lactamases - genetics ; carbapenem ; Carbapenems - pharmacology ; Humans ; metallo-β-lactamase ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - enzymology ; Pseudomonas aeruginosa - isolation & purification
É parte de: Kansenshogaku Zasshi, 2001/08/20, Vol.75(8), pp.662-670
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: We tested the antimicrobial activities of meropenem (MEPM), imipenem (IPM), panipenem (PAPM), piperacillin (PIPC), cefepime (CFPM), aztreonam (AZT), amikacin (AMK), and levofloxacin (LVFX) against 106 clinical Pseudomonas aeruginosa isolates and 64 clinical Acinetobacter spp. iso lates with reduced susceptibility to carbapenems. Using NCCLS breakpoints, the percentages of P. aeruginosa strains susceptible to AMK and Acinetobacter spp. strains susceptible to LVFX were found to be 51.1% and 55.6%, respectively, which represented the highest activity among 8 antimicrobial agents in each organism. Referring to the correlations among MICs of carbapenems, MEPM showed a higher activity than IPM and PAPM in both organisms; 29 of the 94 strains (30.9%) of IPMresistant P. aeruginosa were susceptible to MEPM. Further study for resistance mechanisms to carbapenems by the disk diffusion method using 2-mercaptopropionic acid revealed that 8 of the 64 Acinetobacter spp. isolates (12.5%) were metallo-β-lactamase producers, while none of 106 P. aeruginosa isolates were metallo-β-lactamase producers. PCR analysis using blaIMP-specific primers confirmed that 4 of the 8 metallo-β-lactamase-producing Acinetobacter spp. isolates detected by the disk diffusion method were carrying the blaIMP gene. The identification of metallo-β-lactamase-producing Acinetobacter spp. isolates implies that metallo-β-lactamase genes have been disseminated among various gramnegative pathogens.
Editor: Japan: The Japanese Association for Infectious Diseases
Idioma: Japonês;Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Antimicrobial Activities and Mechanisms of Carbapenem Resistance in Clinical Isolates of Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp

SUGINO, Yasuteru ; IINUMA, Yoshitsugu ; NADA, Toshi ; TAWADA, Yukio ; AMANO, Hiroshi ; NAKAMURA, Tadahiro ; HASEGAWA, Yoshinori ; SHIMOKATA, Kaoru ; SHIBATA, Naohiro ; ARAKAWA, Yoshichika

Japan: The Japanese Association for Infectious Diseases

Buscando em bases de dados remotas. Favor aguardar.