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Food elimination diets are effective for long‐term treatment of adults with eosinophilic oesophagitis

Reed, C. C. ; Fan, C. ; Koutlas, N. T. ; Shaheen, N. J. ; Dellon, E. S.

Alimentary pharmacology & therapeutics, 2017-11, Vol.46 (9), p.836-844 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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  • Título:
    Food elimination diets are effective for long‐term treatment of adults with eosinophilic oesophagitis
  • Autor: Reed, C. C. ; Fan, C. ; Koutlas, N. T. ; Shaheen, N. J. ; Dellon, E. S.
  • Assuntos: Adult ; Adults ; Antigens ; Deglutition Disorders - diagnosis ; Deglutition Disorders - diet therapy ; Deglutition Disorders - pathology ; Deglutition Disorders - physiopathology ; Diet ; Disease control ; Dysphagia ; Endoscopes ; Endoscopy ; Eosinophilic Esophagitis - diagnosis ; Eosinophilic Esophagitis - diet therapy ; Eosinophilic Esophagitis - pathology ; Eosinophilic Esophagitis - physiopathology ; Eosinophils ; Esophagitis ; Female ; Food ; Humans ; Leukocytes (eosinophilic) ; Male ; Middle Aged ; Reintroduction ; Retrospective Studies ; Steroid hormones ; Steroids ; Treatment Outcome
  • É parte de: Alimentary pharmacology & therapeutics, 2017-11, Vol.46 (9), p.836-844
  • Notas: Funding information
    This article is linked to Gonsalves and Hiranol paper. To view this article visit
    Linked Content
    https://doi.org/10.1111/apt.14379
    .
    This research was supported, in part, by NIH awards T32DK007634 CCR and K23DK090073 (ESD). None of the authors have potential conflicts related to the current manuscript.
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    SourceType-Scholarly Journals-1
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  • Descrição: Summary Background Limited data describe the long‐term efficacy of dietary elimination in eosinophilic oesophagitis (EoE). Aim To assess the long‐term outcomes of food elimination diets for treatment of adults with EoE. Methods We conducted a retrospective cohort study at our centre analysing all EoE patients receiving a food elimination diet without concomitant steroids. Baseline data were ed using standardised collection forms. Follow‐up data from a mean 24.9‐month period were collected for patients with a histological response to a food elimination diet during and after food reintroduction. The main outcomes were symptomatic, endoscopic and histological responses. Results Of 52 patients, 18 received a 6‐food food elimination diet, 32 received targeted diet, and two received a 6‐food food elimination diet with targeted elimination. There were 21 (40%) patients with an initial histological response. Responders reported less dysphagia after treatment (95% baseline vs 11%; P = .001) and at the end of follow‐up (95% baseline vs 33%; P = .008). Significant and durable endoscopic improvements were recorded at the same time points: Endoscopic reference score: 3.2 vs 0.7; P = .001; and 3.2 vs 1.7; P = .06. Histological findings improved after the most restrictive diet in responders (49.8 vs 4.1 eosinophils per high‐power field; P = .001) and remained suppressed in the 10 initial responders maintaining compliance at the end of follow‐up (5.2 eosinophils per high‐power field). Conclusions Among EoE patients responding to a food elimination diet and remaining adherent, maintenance dietary therapy produced durable long‐term symptomatic, endoscopic and histological disease control. These long‐term data confirm that a food elimination diet is an effective maintenance treatment option in select adults with EoE. Linked ContentThis article is linked to Gonsalves and Hiranol paper. To view this article visit https://doi.org/10.1111/apt.14379.
  • Editor: England: Wiley Subscription Services, Inc
  • Idioma: Inglês
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