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Secondhand smoke and traffic exhaust confer opposing risks for asthma in normal and overweight children

LeMasters, Grace ; Levin, Linda ; Bernstein, David I. ; Lockey, Stephen D. ; Lockey, James E. ; Burkle, Jeff ; Khurana Hershey, Gurjit K. ; Brunst, Kelly ; Ryan, Patrick H.

Obesity (Silver Spring, Md.), 2015-01, Vol.23 (1), p.32-36 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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  • Título:
    Secondhand smoke and traffic exhaust confer opposing risks for asthma in normal and overweight children
  • Autor: LeMasters, Grace ; Levin, Linda ; Bernstein, David I. ; Lockey, Stephen D. ; Lockey, James E. ; Burkle, Jeff ; Khurana Hershey, Gurjit K. ; Brunst, Kelly ; Ryan, Patrick H.
  • Assuntos: Age ; Asthma ; Asthma - epidemiology ; Asthma - etiology ; Body Mass Index ; Child ; Children & youth ; Confidence intervals ; Education ; Female ; Hair ; Humans ; Hypotheses ; Ideal Body Weight - physiology ; Inhalation Exposure - adverse effects ; Inhalation Exposure - statistics & numerical data ; Logistic Models ; Male ; Obesity ; Odds Ratio ; Outdoor air quality ; Overweight - complications ; Overweight - epidemiology ; Prevalence ; Risk Factors ; Tobacco Smoke Pollution - adverse effects ; Tobacco Smoke Pollution - statistics & numerical data ; Vehicle Emissions - toxicity
  • É parte de: Obesity (Silver Spring, Md.), 2015-01, Vol.23 (1), p.32-36
  • Notas: Disclosures
    Funding for this study was provided by grants NIEHS R01ES11170 and R01ES019890 from the National Institute of Environmental Health Sciences.
    The authors declared no conflict of interest.
    Funding agencies
    Author contributions
    GL is the principal investigator and the epidemiologist who designed the study and participated in all data analyses and wrote the manuscript. LL is the senior statistician involved in the data analysis, DB is an allergist whose group did most of the clinical exams, SL participated in the review of the literature and data analysis, JL is the pulmonary medicine physician who assisted in the study design and review of all asthmatic cases, did quality control of the PFT, and participated in manuscript preparation, JB is the data manager who maintains all the data sets and generated all the variables, GJ is a pediatric allergist who participated in the study design and manuscript preparation, KB assisted with initial data analysis and literature review, and PR assisted with the data analysis and manuscript preparation.
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
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  • Descrição: Objective Exposure to ultrafine particles (UFP) in secondhand smoke (SHS) and traffic‐related air pollution (TRAP) may elicit chronic inflammation. It was hypothesized that the association between these exposures would be potentiated in overweight versus normal‐weight children. Methods Average lifetime exposure to TRAP and SHS and objective, physician‐diagnosed asthma were determined for 575 children at age 7. Overweight was defined as having a body mass index (BMI) >85th percentile for age and gender. The association between TRAP and SHS exposure and asthma was examined by logistic regression stratified by BMI. Results A total of 131 children were overweight; the prevalence of asthma was 24.4% and 14.2% among overweight and normal‐weight children, respectively. Exposure to SHS was significantly associated with asthma among overweight (adjusted odds ratio [adjOR] = 3.0; 95% confidence interval [CI] = 1.2, 7.4) but not normal‐weight children (adjOR = 1.1; 95% CI = 0.4, 2.7). In contrast, TRAP was significantly associated with asthma among normal‐weight (adjOR = 1.8; 95% CI = 1.0, 3.4) but not overweight children (adjOR = 0.7; 95% CI = 0.4, 2.7). Conclusions The association between SHS and TRAP exposure and asthma is modified by children's weight. Children's time‐activity patterns, including time spent indoors or outdoors, may vary by weight and play an important role in these UFP exposures.
  • Editor: United States: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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