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Effect of synthetic peptide thrombin receptor agonist encapsulated in microparticles based on lactic and glycolic acid copolymer on healing of experimental skin wounds in mice

Dugina, T N ; Kiseleva, E V ; Lange, M A ; Vasil'eva, T V ; Grandfils, C ; Markvicheva, E A ; Bespalova, Zh D ; Pal'keeva, M E ; Strukova, S M

Bulletin of experimental biology and medicine, 2004-11, Vol.138 (5), p.463-466 [Periódico revisado por pares]

United States: Springer Nature B.V

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Título:
Effect of synthetic peptide thrombin receptor agonist encapsulated in microparticles based on lactic and glycolic acid copolymer on healing of experimental skin wounds in mice
Autor: Dugina, T N ; Kiseleva, E V ; Lange, M A ; Vasil'eva, T V ; Grandfils, C ; Markvicheva, E A ; Bespalova, Zh D ; Pal'keeva, M E ; Strukova, S M
Assuntos: Animals ; Biochemistry, biophysics & molecular biology ; Biochimie, biophysique & biologie moléculaire ; Drug Carriers ; Female ; Fibroblasts - drug effects ; Fibroblasts - physiology ; Kinetics ; Lactic Acid ; Life sciences ; Macrophages - drug effects ; Macrophages - physiology ; Mice ; peptide agonists ; Peptide Fragments - therapeutic use ; Polyglycolic Acid ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polymers ; protease activated receptors ; Receptor, PAR-1 - agonists ; Sciences du vivant ; Skin - drug effects ; Skin - injuries ; Skin - physiopathology ; thrombin ; wound healing ; Wound Healing - physiology
É parte de: Bulletin of experimental biology and medicine, 2004-11, Vol.138 (5), p.463-466
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
scopus-id:2-s2.0-15544391136
Descrição: PAR1 peptide thrombin receptor agonist (PAR1-AP) was encapsulated in microcorpuscles based on lactic and glycolic acid copolymer. The desorption profile of the preparation was studied in vitro and its wound-healing effects were studied on a model of cut skin wound in mice. The study showed that 90% PAR1-AP was desorbed over 6 h, but the peptide was detected in eluates from the microparticle surface after 23 h. The desorbed peptide retained its physiological activity and was capable of activating PAR1 receptors on human platelets. The study of the dynamics of experimental skin wound healing in mice showed lower number of macrophages in the wounds treated with PAR1-AP microparticles compared to the control (open wounds and wounds covered with microparticles) and higher number of fibroblasts on day 3 of tissue reparation. Hence, PAR1-AP desorbed from microparticles shortened the inflammation phase in the wound. On day 7 the best healing parameters were also observed in wounds treated with PAR1-AP microparticles, which attests to shortening of the proliferation phase and acceleration of wound healing.
Editor: United States: Springer Nature B.V
Idioma: Inglês

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Effect of synthetic peptide thrombin receptor agonist encapsulated in microparticles based on lactic and glycolic acid copolymer on healing of experimental skin wounds in mice

Dugina, T N ; Kiseleva, E V ; Lange, M A ; Vasil'eva, T V ; Grandfils, C ; Markvicheva, E A ; Bespalova, Zh D ; Pal'keeva, M E ; Strukova, S M

United States: Springer Nature B.V

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