skip to main content
Idioma:

Endogenous opiate analgesia induced by tonic immobility in guinea pigs

Leite-Panissi, C R ; Rodrigues, C L ; Brentegani, M R ; Menescal-De-Oliveira, L

Brazilian journal of medical and biological research, 2001-02, Vol.34 (2), p.245-250 [Periódico revisado por pares]

Brazil: Associação Brasileira de Divulgação Científica

Texto completo disponível

Citações Citado por
  • Título:
    Endogenous opiate analgesia induced by tonic immobility in guinea pigs
  • Autor: Leite-Panissi, C R ; Rodrigues, C L ; Brentegani, M R ; Menescal-De-Oliveira, L
  • Assuntos: analgesia ; Animals ; antinociception ; Behavior, Animal - physiology ; BIOLOGY ; guinea pig ; Guinea Pigs ; Immobilization - physiology ; Male ; MEDICINE, RESEARCH & EXPERIMENTAL ; naloxone ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; Opioid Peptides - antagonists & inhibitors ; Opioid Peptides - metabolism ; opioids ; tonic immobility
  • É parte de: Brazilian journal of medical and biological research, 2001-02, Vol.34 (2), p.245-250
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: A function of the endogenous analgesic system is to prevent recuperative behaviors generated by tissue damage, thus preventing the emission of species-specific defensive behaviors. Activation of intrinsic nociception is fundamental for the maintenance of the behavioral strategy adopted. Tonic immobility (TI) is an inborn defensive behavior characterized by a temporary state of profound and reversible motor inhibition elicited by some forms of physical restraint. We studied the effect of TI behavior on nociception produced by the formalin and hot-plate tests in guinea pigs. The induction of TI produced a significant decrease in the number of flinches (18 +/- 6 and 2 +/- 1 in phases 1 and 2) and lickings (6 +/- 2 and 1 +/- 1 in phases 1 and 2) in the formalin test when compared with control (75 +/- 13 and 22 +/- 6 flinches in phases 1 and 2; 28 +/- 7 and 17 +/- 7 lickings in phases 1 and 2). In the hot-plate test our results also showed antinociceptive effects of TI, with an increase in the index of analgesia 30 and 45 min after the induction of TI (0.67 +/- 0.1 and 0.53 +/- 0.13, respectively) when compared with control (-0.10 +/- 0.08 at 30 min and -0.09 +/- 0.09 at 45 min). These effects were reversed by pretreatment with naloxone (1 mg/kg, ip), suggesting that the hypoalgesia observed after induction of TI behavior, as evaluated by the algesimetric formalin and hot-plate tests, is due to activation of endogenous analgesic mechanisms involving opioid synapses.
  • Editor: Brazil: Associação Brasileira de Divulgação Científica
  • Idioma: Inglês;Português
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.