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Cyclic-AMP inhibition of fimbriae and prodigiosin production by Serratia marcescens is strain-dependent

Stella, Nicholas A ; Shanks, Robert M. Q

Archives of microbiology, 2014-05, Vol.196 (5), p.323-330 [Periódico revisado por pares]

Berlin/Heidelberg: Springer-Verlag

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Título:
Cyclic-AMP inhibition of fimbriae and prodigiosin production by Serratia marcescens is strain-dependent
Autor: Stella, Nicholas A ; Shanks, Robert M. Q
Assuntos: 3',5'-Cyclic-AMP Phosphodiesterases - genetics ; adenosine monophosphate ; agglutination ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Cell Biology ; cyclic AMP ; Cyclic AMP - metabolism ; Cyclic AMP Receptor Protein - genetics ; Ecology ; fimbriae ; Fimbriae, Bacterial - metabolism ; Gene Expression Regulation ; Gene Expression Regulation, Bacterial ; genes ; genetic engineering ; Life Sciences ; Microbial Ecology ; Microbiology ; Mutation ; Original Paper ; phenotype ; Prodigiosin - biosynthesis ; prokaryotic cells ; secondary metabolites ; Serratia marcescens ; Serratia marcescens - genetics ; Serratia marcescens - metabolism ; yeasts
É parte de: Archives of microbiology, 2014-05, Vol.196 (5), p.323-330
Notas: http://dx.doi.org/10.1007/s00203-014-0970-6
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Descrição: The cyclic-nucleotide 3′,5′-cyclic AMP (cAMP) is an ancient and widespread regulatory molecule. Previous studies have shown that fimbria production and secondary metabolite production are inhibited by cAMP in the prokaryote Serratia marcescens. This study used genetic manipulations to test the strain specificity of cAMP–cyclic-AMP receptor protein regulation of fimbria production and of the red pigment, prodigiosin. A surprising amount of variation was observed, as multicopy expression of the cAMP-phosphodiesterase gene, cpdS, conferred either an increase or decrease in fimbriae-dependent yeast agglutination and prodigiosin production depending upon the strain background. Mutation of crp, the gene coding for the cAMP-receptor protein, similarly conferred strain-dependent phenotypes. This study shows that three distinct biological properties, modulated by a conserved genetic regulatory molecule, can vary significantly among strains. Such variation can complicate the functional analysis of bacterial phenotypic properties which are dependent upon global genetic regulators such as cAMP.
Editor: Berlin/Heidelberg: Springer-Verlag
Idioma: Inglês

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Cyclic-AMP inhibition of fimbriae and prodigiosin production by Serratia marcescens is strain-dependent

Stella, Nicholas A ; Shanks, Robert M. Q

Berlin/Heidelberg: Springer-Verlag

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