Idioma:

The ubiquitin-proteasome pathway and proteasome inhibitors

Myung, Jayhyuk ; Kim, Kyung Bo ; Crews, Craig M.

Medicinal research reviews, 2001-07, Vol.21 (4), p.245-273 [Periódico revisado por pares]

New York: John Wiley & Sons, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
The ubiquitin-proteasome pathway and proteasome inhibitors
Autor: Myung, Jayhyuk ; Kim, Kyung Bo ; Crews, Craig M.
Assuntos: Biological and medical sciences ; Cell metabolism, cell oxidation ; Cell physiology ; Cysteine Endopeptidases - metabolism ; Cysteine Proteinase Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; Humans ; Molecular and cellular biology ; Multienzyme Complexes - metabolism ; natural product ; Proteasome Endopeptidase Complex ; proteasome inhibitor ; protein degradation ; ubiquitin-proteasome pathway ; Ubiquitins - metabolism
É parte de: Medicinal research reviews, 2001-07, Vol.21 (4), p.245-273
Notas: istex:66C8AC5B84A84C224A4C9C4B694BCF657622752E
ArticleID:MED1009
ark:/67375/WNG-J3CG88XS-Z
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and examples of human diseases resulting from defects in various components of the ubiquitin‐proteasome pathway. In addition, this review covers the chemistry of synthetic and natural proteasome inhibitors, emphasizing their mode of actions toward the 20S proteasome. Given the importance of proteasome‐mediated protein degradation in various intracellular processes, inhibitors of this pathway will continue to serve as both molecular probes of major cellular networks as well as potential therapeutic agents for various human diseases. © 2001 John Wiley & Sons, Inc. Med Res Rev, 21, No. 4, 245–273, 2001
Editor: New York: John Wiley & Sons, Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

The ubiquitin-proteasome pathway and proteasome inhibitors

Myung, Jayhyuk ; Kim, Kyung Bo ; Crews, Craig M.

New York: John Wiley & Sons, Inc

Buscando em bases de dados remotas. Favor aguardar.