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Erosive hand osteoarthritis and sarcopenia: data from Osteoarthritis Initiative cohort

Moradi, Kamyar ; Kwee, Robert M ; Mohajer, Bahram ; Guermazi, Ali ; Roemer, Frank W ; Ibad, Hamza Ahmed ; Haugen, Ida K ; Berenbaum, Francis ; Demehri, Shadpour

Annals of the rheumatic diseases, 2024-01, Vol.83 (6), p.ard-2023-224997-806 [Periódico revisado por pares]

England: BMJ Publishing Group Ltd and European League Against Rheumatism

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  • Título:
    Erosive hand osteoarthritis and sarcopenia: data from Osteoarthritis Initiative cohort
  • Autor: Moradi, Kamyar ; Kwee, Robert M ; Mohajer, Bahram ; Guermazi, Ali ; Roemer, Frank W ; Ibad, Hamza Ahmed ; Haugen, Ida K ; Berenbaum, Francis ; Demehri, Shadpour
  • Assuntos: Adipose tissue ; Arthritis ; Automation ; Biomarkers ; Body fat ; Chronic illnesses ; Cohort analysis ; Datasets ; Deep learning ; Females ; Imaging ; Inflammation ; Machine Learning ; Magnetic Resonance Imaging ; Missing data ; Muscle contraction ; Muscles ; Musculoskeletal system ; Older people ; Osteoarthritis ; Quadriceps muscle ; Regression analysis ; Sarcopenia
  • É parte de: Annals of the rheumatic diseases, 2024-01, Vol.83 (6), p.ard-2023-224997-806
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: ObjectivesThere is no evidence linking specific osteoarthritis (OA) types, such as erosive hand OA (EHOA), with distant generalised changes in muscle composition (sarcopenia), which can potentially be modified. This study pioneers the exploration of the association between EHOA and sarcopenia, both of which are predominantly observed in the older adults.MethodsUsing the Osteoarthritis Initiative cohort, we selected hand OA (modified Kellgren and Lawrence (grade ≥2 in ≥1 hand joint) participants with radiographic central erosions in ≥1 joints (EHOA group) and propensity score-matched hand OA participants with no erosion (non-EHOA group). MRI biomarkers of thigh muscles were measured at baseline, year 2 and year 4 using a validated deep-learning algorithm. To adjust for ‘local’ effects of coexisting knee OA (KOA), participants were further stratified according to presence of radiographic KOA. The outcomes were the differences between EHOA and non-EHOA groups in the 4-year rate of change for both intramuscular adipose tissue (intra-MAT) deposition and contractile (non-fat) area of thigh muscles.ResultsAfter adjusting for potential confounders, 844 thighs were included (211 EHOA:633 non-EHOA; 67.1±7.5 years, female/male:2.9). Multilevel mixed-effect regression models showed that EHOA is associated a different 4-year rate of change in intra-MAT deposition (estimate, 95% CI: 71.5 mm2/4 years, 27.9 to 115.1) and contractile area (estimate, 95% CI: −1.8%/4 years, −2.6 to −1.0) of the Quadriceps. Stratified analyses showed that EHOA presence is associated with adverse changes in thigh muscle quality only in participants without KOA.ConclusionsEHOA is associated with longitudinal worsening of thigh muscle composition only in participants without concomitant KOA. Further research is needed to understand the systemic factors linking EHOA and sarcopenia, which unlike EHOA is modifiable through specific interventions.
  • Editor: England: BMJ Publishing Group Ltd and European League Against Rheumatism
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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