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Metformin alters dendrite development and synaptic plasticity in rat cortical neurons

Oner, Muhammet ; Cheng, Pang-Ting ; Wang, Hsin-Yi ; Chen, Mei-Chih ; Lin, Ho

Biochemical and biophysical research communications, 2024-05, Vol.710, p.149874-149874, Article 149874 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Metformin alters dendrite development and synaptic plasticity in rat cortical neurons
  • Autor: Oner, Muhammet ; Cheng, Pang-Ting ; Wang, Hsin-Yi ; Chen, Mei-Chih ; Lin, Ho
  • Assuntos: Animals ; Blood-Brain Barrier ; Dendrite development ; Dendrites ; Female ; Learning ; Metformin ; Neuronal Plasticity - physiology ; Neurons ; Pregnancy ; Rats ; Synaptic density ; Synaptic plasticity
  • É parte de: Biochemical and biophysical research communications, 2024-05, Vol.710, p.149874-149874, Article 149874
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Synaptic plasticity is crucial as it dynamically molds the strength and connectivity of neural circuits, influencing learning, memory, and the development of neurological disorders. Metformin, a widely prescribed anti-diabetic medication, has been shown to readily cross the blood-brain barrier (BBB) and the placenta. However, its prolonged impact on neuronal morphology and functions remains underexplored. In this study, we investigated the influence of metformin on dendrite development and synaptic plasticity in embryonic brains and primary rat cortical neurons. Our findings reveal a negative modulation of dendrite development by metformin, as evidenced by altered dendritic arborization, impaired dendritic spine morphology and disruptions in synaptic plasticity, suggesting a potential link between metformin exposure and aberrations in neuronal connectivity. In addition, we extend our insights to the impact of maternal metformin exposure on embryonic brains, revealing a significant inhibition of dendrite development in E18.5 rat brains. In conclusion, this study adds to the expanding knowledge base on the non-metabolic effects of metformin, emphasizing the significance of assessing its potential influence on both neuronal structure and function. There is an urgent need for further investigations into the enduring impact of prolonged metformin administration on the structural and functional aspects of neurons. [Display omitted] •Metformin impairs dendrite development in the developing cortex and cortical neurons likely by targeting Map2.•Metformin alters dendritic spine morphology in primary cortical neurons.•Metformin reduces dendritic arborization and synaptic plasticity in primary cortical neurons.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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