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Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients

Rojkó, Lívia ; Reiniger, Lilla ; Téglási, Vanda ; Fábián, Katalin ; Pipek, Orsolya ; Vágvölgyi, Attila ; Agócs, László ; Fillinger, János ; Kajdácsi, Zita ; Tímár, József ; Döme, Balázs ; Szállási, Zoltán ; Moldvay, Judit

Journal of cancer research and clinical oncology, 2018-07, Vol.144 (7), p.1219-1226 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients
Autor: Rojkó, Lívia ; Reiniger, Lilla ; Téglási, Vanda ; Fábián, Katalin ; Pipek, Orsolya ; Vágvölgyi, Attila ; Agócs, László ; Fillinger, János ; Kajdácsi, Zita ; Tímár, József ; Döme, Balázs ; Szállási, Zoltán ; Moldvay, Judit
Assuntos: Adenocarcinoma - drug therapy ; Adenocarcinoma - immunology ; Adenocarcinoma - pathology ; Adenocarcinoma of Lung ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Apoptosis ; B7-H1 Antigen - biosynthesis ; B7-H1 Antigen - immunology ; Biopsy ; Bronchoscopy ; Cancer Research ; Cancer therapies ; Carboplatin ; Carboplatin - administration & dosage ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - immunology ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - pathology ; Cell death ; Chemotherapy ; Cisplatin ; Cisplatin - administration & dosage ; Deoxycytidine - administration & dosage ; Deoxycytidine - analogs & derivatives ; Female ; Gemcitabine ; Hematology ; Humans ; Immune checkpoint ; Immunohistochemistry ; Internal Medicine ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - pathology ; Lung cancer ; Lung Neoplasms - drug therapy ; Lung Neoplasms - immunology ; Lung Neoplasms - pathology ; Male ; Medicine ; Medicine & Public Health ; Metastases ; Middle Aged ; Neoadjuvant Therapy ; Non-small cell lung carcinoma ; Oncology ; Original Article – Cancer Research ; Paclitaxel ; Paclitaxel - administration & dosage ; Patients ; PD-1 protein ; PD-L1 protein ; Platinum ; Programmed Cell Death 1 Receptor - biosynthesis ; Programmed Cell Death 1 Receptor - immunology ; Squamous cell carcinoma ; Tumor cells
É parte de: Journal of cancer research and clinical oncology, 2018-07, Vol.144 (7), p.1219-1226
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SourceType-Scholarly Journals-1
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Descrição: Objectives While the predictive value of programmed cell death ligand-1 (PD-L1) protein expression for immune checkpoint inhibitor therapy of lung cancer has been extensively studied, the impact of standard platinum-based chemotherapy on PD-L1 or programmed cell death-1 (PD-1) expression is unknown. The aim of this study was to determine the changes in PD-L1 expression of tumor cells (TC) and immune cells (IC), in PD-1 expression of IC, and in the amount of stromal mononuclear cell infiltration after platinum-based chemotherapy in patients with lung cancer. Materials and methods We determined the amount of stromal mononuclear cells and PD-L1/PD-1 expressions by immunohistochemistry in bronchoscopic biopsy samples including 20 adenocarcinomas (ADC), 15 squamous cell carcinomas (SCC), 2 other types of non-small cell lung cancer, and 4 small cell lung cancers together with their corresponding surgical resection tissues after platinum-based chemotherapy. Results PD-L1 expression of TC decreased in ten patients (24.4%) and increased in three patients (7.32%) after neoadjuvant chemotherapy ( p = 0.051). The decrease in PD-L1 expression, however, was significant only in patients who received cisplatin–gemcitabine combination ( p = 0.020), while in the carboplatin–paclitaxel group, no similar tendency could be observed ( p = 0.432). There was no difference between ADC and SCC groups. Neither PD-1 expression nor the amount of stromal IC infiltration showed significant changes after chemotherapy. Conclusions This is the first study, in which both PD-L1 and PD-1 expression were analyzed together with the amount of stromal IC infiltration in different histological subtypes of lung cancer before and after platinum-based chemotherapy. Our results confirm that chemotherapy decreases PD-L1 expression of TC in a subset of patients, therefore, rebiopsy and re-evaluation of PD-L1 expression may be necessary for the indication of immune checkpoint inhibitor therapy.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients

Rojkó, Lívia ; Reiniger, Lilla ; Téglási, Vanda ; Fábián, Katalin ; Pipek, Orsolya ; Vágvölgyi, Attila ; Agócs, László ; Fillinger, János ; Kajdácsi, Zita ; Tímár, József ; Döme, Balázs ; Szállási, Zoltán ; Moldvay, Judit

Berlin/Heidelberg: Springer Berlin Heidelberg

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