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Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects

Edr, Antonín ; Wrobel, Dominika ; Krupková, Alena ; Šťastná, Lucie Červenková ; Cuřínová, Petra ; Novák, Aleš ; Malý, Jan ; Kalasová, Jitka ; Malý, Jan ; Malý, Marek ; Strašák, Tomáš

International journal of molecular sciences, 2022-02, Vol.23 (4), p.2114 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects
Autor: Edr, Antonín ; Wrobel, Dominika ; Krupková, Alena ; Šťastná, Lucie Červenková ; Cuřínová, Petra ; Novák, Aleš ; Malý, Jan ; Kalasová, Jitka ; Malý, Jan ; Malý, Marek ; Strašák, Tomáš
Assuntos: AMP ; amphiphiles ; Anthracenes - chemistry ; carbosilane ; Computer Simulation ; dendrons ; DLS ; Drug delivery ; Drug delivery systems ; Hydrocarbons ; Hydrophobic and Hydrophilic Interactions ; Investigations ; Libraries ; Membranes ; Micelles ; Molecular dynamics ; Molecular modelling ; Nanoparticles ; Nanoparticles - chemistry ; Self assembly ; Silanes - chemistry ; Spatial distribution ; Water - chemistry ; zeta potential
É parte de: International journal of molecular sciences, 2022-02, Vol.23 (4), p.2114
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Supramolecular structures, such as micelles, liposomes, polymerosomes or dendrimerosomes, are widely studied and used as drug delivery systems. The behavior of amphiphilic building blocks strongly depends on their spatial distribution and shape of polar and nonpolar component. This report is focused on the development of new versatile synthetic protocols for amphiphilic carbosilane dendrons (amp-CS-DDNs) capable of self-assembly to regular micelles and other supramolecular objects. The presented strategy enables the fine modification of amphiphilic structure in several ways and also enables the facile connection of a desired functionality. DLS experiments demonstrated correlations between structural parameters of amp-CS-DDNs and the size of formed nanoparticles. For detailed information about the organization and spatial distribution of amp-CS-DDNs assemblies, computer simulation models were studied by using molecular dynamics in explicit water.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects

Edr, Antonín ; Wrobel, Dominika ; Krupková, Alena ; Šťastná, Lucie Červenková ; Cuřínová, Petra ; Novák, Aleš ; Malý, Jan ; Kalasová, Jitka ; Malý, Jan ; Malý, Marek ; Strašák, Tomáš

Switzerland: MDPI AG

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