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MHC polymorphism in Caribbean African green monkeys

Aarnink, A. ; Jacquelin, B. ; Dauba, A. ; Hébrard, S. ; Moureaux, E. ; Müller-Trutwin, M. ; Blancher, A.

Immunogenetics (New York), 2014-06, Vol.66 (6), p.353-360 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
MHC polymorphism in Caribbean African green monkeys
Autor: Aarnink, A. ; Jacquelin, B. ; Dauba, A. ; Hébrard, S. ; Moureaux, E. ; Müller-Trutwin, M. ; Blancher, A.
Assuntos: Allergology ; Animal models ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Caribbean Region ; Cell Biology ; Cercopithecus aethiops/genetics ; Cercopithecus aethiops/immunology ; Chlorocebus aethiops - genetics ; Chlorocebus aethiops - immunology ; Cynomolgus ; Expressed Sequence Tags ; Female ; Founder Effect ; Gene Function ; Genetics ; Genotyping ; Genotyping Techniques ; Haplotypes ; Human Genetics ; Immunology ; Islands ; Life Sciences ; Macaca ; Major histocompatibility complex ; Major Histocompatibility Complex - genetics ; Major Histocompatibility Complex - immunology ; Male ; Medical research ; Microsatellite Repeats - immunology ; Microsatellites ; Monkeys ; Monkeys & apes ; Original Paper ; Polymorphism ; Polymorphism, Genetic ; Populations ; Primates ; Sequence Analysis, DNA
É parte de: Immunogenetics (New York), 2014-06, Vol.66 (6), p.353-360
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Descrição: African green monkeys (AGM) are among the most widely used nonhuman primate models used in various fields of medical research. One species of AGM that originated from West Africa, Chlorocebus sabaeus , was introduced three centuries ago in the Caribbean islands. We present here a systematic study of the major histocompatibility complex (MHC) polymorphism of Caribbean AGM which is currently frequently used as an animal model. We studied 54 animals originated from Barbados ( N = 25) or Saint Kitts ( N = 29). The MHC polymorphism was characterized by means of 17 MHC microsatellites spread across MHC and DRB genotyping by DGGE sequencing. We defined nine frequent MHC haplotypes of which two were found in the two insular populations suggesting either past exchanges between the two populations or a common origin of the founders of the two populations. By the analysis of a previously described EST library, we characterized 38 MHC cDNA sequences (17 class I and 21 class II). In conclusion, we characterized for the first time the MHC polymorphism of Barbados and Saint Kitts AGM. We found a restricted polymorphism due to a founding effect, which is responsible for a strong bottleneck. The poorness of MHC polymorphism observed in the Caribbean AGM populations is similar to that observed in the Mauritian cynomolgus macaque population.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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MHC polymorphism in Caribbean African green monkeys

Aarnink, A. ; Jacquelin, B. ; Dauba, A. ; Hébrard, S. ; Moureaux, E. ; Müller-Trutwin, M. ; Blancher, A.

Berlin/Heidelberg: Springer Berlin Heidelberg

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