Idioma:

Three Years of Progress Toward Achieving Hepatitis C Elimination in the Country of Georgia, April 2015–March 2018

Tsertsvadze, Tengiz ; Gamkrelidze, Amiran ; Chkhartishvili, Nikoloz ; Abutidze, Akaki ; Sharvadze, Lali ; Kerashvili, Vakhtang ; Butsashvili, Maia ; Metreveli, David ; Gvinjilia, Lia ; Shadaker, Shaun ; Nasrullah, Muazzam ; Adamia, Ekaterine ; Zeuzem, Stefan ; Afdhal, Nezam ; Arora, Sanjeev ; Thornton, Karla ; Skaggs, Beth ; Kuchuloria, Tinatin ; Lagvilava, Maia ; Sergeenko, David ; Averhoff, Francisco

Clinical infectious diseases, 2020-08, Vol.71 (5), p.1263-1268 [Periódico revisado por pares]

US: Oxford University Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Three Years of Progress Toward Achieving Hepatitis C Elimination in the Country of Georgia, April 2015–March 2018
Autor: Tsertsvadze, Tengiz ; Gamkrelidze, Amiran ; Chkhartishvili, Nikoloz ; Abutidze, Akaki ; Sharvadze, Lali ; Kerashvili, Vakhtang ; Butsashvili, Maia ; Metreveli, David ; Gvinjilia, Lia ; Shadaker, Shaun ; Nasrullah, Muazzam ; Adamia, Ekaterine ; Zeuzem, Stefan ; Afdhal, Nezam ; Arora, Sanjeev ; Thornton, Karla ; Skaggs, Beth ; Kuchuloria, Tinatin ; Lagvilava, Maia ; Sergeenko, David ; Averhoff, Francisco
Assuntos: Adolescent ; Adult ; Antiviral Agents - therapeutic use ; Georgia (Republic) - epidemiology ; Georgia - epidemiology ; Hepacivirus - genetics ; Hepatitis C - diagnosis ; Hepatitis C - drug therapy ; Hepatitis C - epidemiology ; Hepatitis C, Chronic - diagnosis ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - epidemiology ; Humans ; Sofosbuvir - therapeutic use ; Sustained Virologic Response
É parte de: Clinical infectious diseases, 2020-08, Vol.71 (5), p.1263-1268
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Background In April 2015, in collaboration with the US Centers for Disease Control and Prevention and Gilead Sciences, the country of Georgia embarked on the world’s first hepatitis C elimination program. We aimed to assess progress toward elimination targets 3 years after the start of the elimination program. Methods We constructed a hepatitis C virus (HCV) care cascade for adults in Georgia, based on the estimated 150 000 persons aged ≥18 years with active HCV infection. All patients who were screened or entered the treatment program during April 2015–March 2018 were included in the analysis. Data on the number of persons screened for HCV were extracted from the national HCV screening database. For the treatment component, we utilized data from the Georgia National HCV treatment program database. Available treatment options included sofosbuvir and ledipasvir/sofosbuvir–based regimens. Results Since April 2015, a cumulative 974 817 adults were screened for HCV antibodies; 86 624 persons tested positive, of whom 61 925 underwent HCV confirmatory testing. Among the estimated 150 000 adults living with chronic hepatitis C in Georgia, 52 856 (35.1%) were diagnosed, 45 334 (30.2%) initiated treatment with direct-acting antivirals, and 29 090 (19.4%) achieved a sustained virologic response (SVR). Overall, 37 256 persons were eligible for SVR assessment; of these, only 29 620 (79.5%) returned for evaluation. The SVR rate was 98.2% (29 090/29 620) in the per-protocol analysis and 78.1% (29 090/37 256) in the intent-to-treat analysis. Conclusions Georgia has made substantial progress in the path toward eliminating hepatitis C. Scaling up of testing and diagnosis, along with effective linkage to treatment services, is needed to achieve the goal of elimination. In April 2015, Georgia launched the world’s first hepatitis C elimination program and achieved significant progress, treating >45 000 persons. High rates of diagnosis, linkage to care, and treatment uptake are needed to achieve the goal of elimination.
Editor: US: Oxford University Press
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Three Years of Progress Toward Achieving Hepatitis C Elimination in the Country of Georgia, April 2015–March 2018

US: Oxford University Press

Buscando em bases de dados remotas. Favor aguardar.