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Intermediacy and Gene–Environment Interaction: The Example of CHRNA5-A3 Region, Smoking, Nicotine Dependence, and Lung Cancer

Wacholder, Sholom ; Chatterjee, Nilanjan ; Caporaso, Neil

JNCI : Journal of the National Cancer Institute, 2008-11, Vol.100 (21), p.1488-1491 [Periódico revisado por pares]

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Título:
Intermediacy and Gene–Environment Interaction: The Example of CHRNA5-A3 Region, Smoking, Nicotine Dependence, and Lung Cancer
Autor: Wacholder, Sholom ; Chatterjee, Nilanjan ; Caporaso, Neil
Assuntos: Addictions ; Chromosomes, Human, Pair 15 ; Genetic Predisposition to Disease ; Genetic Variation ; Genomics ; Humans ; Lung cancer ; Lung Neoplasms - etiology ; Lung Neoplasms - genetics ; Medical research ; Nerve Tissue Proteins - genetics ; Receptors, Nicotinic - genetics ; Risk Assessment ; Risk Factors ; Smoking ; Smoking - adverse effects ; Smoking - genetics ; Tobacco Use Disorder - complications ; Tobacco Use Disorder - genetics
É parte de: JNCI : Journal of the National Cancer Institute, 2008-11, Vol.100 (21), p.1488-1491
Notas: istex:A6C597CC310414FA2A6FE4CF79D024F93B81012C
ark:/67375/HXZ-DGM59HXW-J
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: During the candidate gene era, many studies with a small number of cases investigated a small number of variants in a limited number of genes chosen on the basis of partial knowledge of their function. These studies established only a few genetic risk factors for cancer and other diseases. Remarkably, recent genome-wide association (GWA) studies have produced strong evidence that variation in a number of genomic regions affects risk of disease.
Editor: United States: Oxford University Press
Idioma: Inglês

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