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Pathological synchronization in Parkinson's disease: networks, models and treatments

Hammond, Constance ; Bergman, Hagai ; Brown, Peter

Trends in neurosciences (Regular ed.), 2007-07, Vol.30 (7), p.357-364 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Pathological synchronization in Parkinson's disease: networks, models and treatments
Autor: Hammond, Constance ; Bergman, Hagai ; Brown, Peter
Assuntos: Animals ; Basal Ganglia ; Basal Ganglia - physiopathology ; Biological and medical sciences ; Biological Clocks ; Biological Clocks - physiology ; Brain ; Cellular Biology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Models, Animal ; Fundamental and applied biological sciences. Psychology ; Humans ; Life Sciences ; Medical sciences ; Medical treatment ; Models, Neurological ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Nerve Net ; Nerve Net - physiopathology ; Neurology ; Neurosciences ; Parkinson Disease ; Parkinson Disease - pathology ; Parkinson Disease - physiopathology ; Parkinson Disease - therapy ; Parkinsons disease ; Vertebrates: nervous system and sense organs
É parte de: Trends in neurosciences (Regular ed.), 2007-07, Vol.30 (7), p.357-364
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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Descrição: Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia–cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast , based on presentations at the annual INMED/TINS symposium ( http://inmednet.com/ ).
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Pathological synchronization in Parkinson's disease: networks, models and treatments

Hammond, Constance ; Bergman, Hagai ; Brown, Peter

Oxford: Elsevier Ltd

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