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Inhibition of microsomal triglyceride transfer protein expression and atherogenic risk factor apolipoprotein B100 secretion by tanshinone IIA in HepG2 cells

Kang, Yun-Jeong ; Jin, Un-Ho ; Chang, Hyen-Wook ; Son, Jong-Keun ; Lee, Seung Ho ; Son, Kun-Ho ; Chang, Young-Chae ; Lee, Young-Choon ; Kim, Cheorl-Ho

Phytotherapy research, 2008-12, Vol.22 (12), p.1640-1645 [Periódico revisado por pares]

Chichester, UK: John Wiley & Sons, Ltd

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Título:
Inhibition of microsomal triglyceride transfer protein expression and atherogenic risk factor apolipoprotein B100 secretion by tanshinone IIA in HepG2 cells
Autor: Kang, Yun-Jeong ; Jin, Un-Ho ; Chang, Hyen-Wook ; Son, Jong-Keun ; Lee, Seung Ho ; Son, Kun-Ho ; Chang, Young-Chae ; Lee, Young-Choon ; Kim, Cheorl-Ho
Assuntos: Albumins - metabolism ; Apolipoprotein B-100 ; Apolipoprotein B-100 - drug effects ; Apolipoprotein B-100 - secretion ; Biological and medical sciences ; Carrier Proteins - drug effects ; Carrier Proteins - metabolism ; Cell Line, Tumor ; Diterpenes, Abietane ; Dose-Response Relationship, Drug ; Gene Expression Regulation ; General pharmacology ; Hepatocytes - drug effects ; Humans ; Medical sciences ; microsomal triglyceride transfer protein ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenanthrenes - pharmacology ; Promoter Regions, Genetic ; Proteasome Endopeptidase Complex - metabolism ; Salvia miltiorrhiza - chemistry ; Salviae miltiorrahizae ; Sterol Regulatory Element Binding Protein 1 - metabolism ; Substrate Specificity ; Tanshinone IIA ; Transcription, Genetic ; Triglycerides - metabolism
É parte de: Phytotherapy research, 2008-12, Vol.22 (12), p.1640-1645
Notas: http://dx.doi.org/10.1002/ptr.2542
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Descrição: Salvia miltiorrhiza Bunge is known to be effective for the treatment of cardiovascular diseases. Here, we have isolated tanshinone IIA (T-IIA) from S. miltiorrhiza Bunge. The aim of this study is to address the mechanisms where apolipoprotein B-100 (ApoB) regulation is associated with T-IIA, since T-IIA regulates the lipoprotein metabolism in liver cells. Human HepG2 cells treated with T-IIA for 24 h exerted a dose-dependent inhibitory effect on ApoB secretion together with triglyceride. However, another secretory protein, albumin, was unaffected by T-IIA treatment, indicating that the effect of T-IIA is specific for ApoB secretion. T-IIA decreased the transcription level of microsomal triglyceride transfer protein gene, suggesting that lipoprotein assembly is likely to be involved in the inhibited ApoB secretion. Interestingly, T-IIA inhibited ApoB secretion via a proteasome-dependent pathway. Our results suggest that T-IIA is an influential inhibitor of ApoB secretion and triglyceride secretion in liver cells. Copyright © 2008 John Wiley & Sons, Ltd.
Editor: Chichester, UK: John Wiley & Sons, Ltd
Idioma: Inglês

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Inhibition of microsomal triglyceride transfer protein expression and atherogenic risk factor apolipoprotein B100 secretion by tanshinone IIA in HepG2 cells

Kang, Yun-Jeong ; Jin, Un-Ho ; Chang, Hyen-Wook ; Son, Jong-Keun ; Lee, Seung Ho ; Son, Kun-Ho ; Chang, Young-Chae ; Lee, Young-Choon ; Kim, Cheorl-Ho

Chichester, UK: John Wiley & Sons, Ltd

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