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Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study

Koepp, M J ; Richardson, M P ; Brooks, D J ; Cunningham, V J ; Duncan, J S

Epilepsia (Copenhagen), 1997-10, Vol.38 (10), p.1089-1097 [Periódico revisado por pares]

United States

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Título:
Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study
Autor: Koepp, M J ; Richardson, M P ; Brooks, D J ; Cunningham, V J ; Duncan, J S
Assuntos: Adult ; Analysis of Variance ; Brain - diagnostic imaging ; Brain - drug effects ; Carbon Radioisotopes ; Cerebellum - chemistry ; Cerebellum - diagnostic imaging ; Cerebellum - drug effects ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - drug effects ; Epilepsy, Generalized - diagnostic imaging ; Epilepsy, Generalized - drug therapy ; Female ; Flumazenil ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Receptors, GABA-A - analysis ; Thalamus - chemistry ; Thalamus - diagnostic imaging ; Thalamus - drug effects ; Tomography, Emission-Computed ; Valproic Acid - adverse effects ; Valproic Acid - pharmacology ; Valproic Acid - therapeutic use
É parte de: Epilepsia (Copenhagen), 1997-10, Vol.38 (10), p.1089-1097
Descrição: Previous [11C]flumazenil (FMZ) positron emission tomography (PET) investigations in patients with idiopathic generalized epilepsy (IGE) have demonstrated nonsignificant global cortical decreases in central benzodiazepine gamma-aminobutyric acid A (GABA[A]) receptor (cBZR) binding or focal decreases in the thalamus and increases in the cerebellar nuclei with no changes in cerebral cortex. We previously reported lower [11C]FMZ binding in cerebral cortex of IGE patients treated with valproate (VPA) than in cerebral cortex of controls. We now report high-resolution three-dimensional [11C]FMZ PET studies in a larger number of subjects using an improved method to detect differences in cBZR between IGE patients and controls and a more powerful longitudinal design to determine the functional effect of VPA. We compared parametric images of [11C]FMZ volume of distribution (FMZVD) in 10 IGE patients before and after addition of VPA and in 20 normal subjects. Mean FMZVD was significantly higher in the cerebral cortex (11%, p = 0.009), thalamus (14%, p = 0.018), and cerebellum (15%, p = 0.027) of the 10 IGE patients as compared with that of 20 normal controls. Using statistical parametric mapping, no significant areas of focal abnormality of FMZVD were detected. Addition of VPA was not associated with a significant change in mean FMZVD in any brain area. Our finding of increased FMZVD in IGE could reflect microdysgenesis or a state of cortical hyperexcitability. Our data suggest that short-term VPA therapy does not affect the number of available cBZR in patients with IGE.
Editor: United States
Idioma: Inglês

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Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study

Koepp, M J ; Richardson, M P ; Brooks, D J ; Cunningham, V J ; Duncan, J S

United States

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