Idioma:

Update on FXR Biology: Promising Therapeutic Target?

Han, Chang Yeob

International journal of molecular sciences, 2018-07, Vol.19 (7), p.2069 [Periódico revisado por pares]

Switzerland: MDPI AG

Texto completo disponível

Citações Citado por

Enviar para

Título:
Update on FXR Biology: Promising Therapeutic Target?
Autor: Han, Chang Yeob
Assuntos: Abnormalities ; Adipose tissue ; Bile ; Bile acids ; Biology ; Cardiovascular system ; Deregulation ; Digestive system ; Digestive tract ; Drug development ; Energy balance ; Fibroblast growth factor ; FXR (farnesoid X receptor) ; Glucose metabolism ; Growth factors ; Homeostasis ; Intestinal microflora ; Intestine ; Lipid metabolism ; Liver ; Liver diseases ; Metabolic disorders ; Metabolism ; Microbiota ; Modulation ; Nuclear engineering ; nuclear receptor ; Nuclear safety ; Organs ; Pancreas ; pharmacological application ; Pharmacology ; Proteins ; Review ; Signal transduction ; Therapeutic applications ; Tumorigenesis
É parte de: International journal of molecular sciences, 2018-07, Vol.19 (7), p.2069
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Farnesoid X receptor (FXR), a metabolic nuclear receptor, plays critical roles in the maintenance of systemic energy homeostasis and the integrity of many organs, including liver and intestine. It regulates bile acid, lipid, and glucose metabolism, and contributes to inter-organ communication, in particular the enterohepatic signaling pathway, through bile acids and fibroblast growth factor-15/19 (FGF-15/19). The metabolic effects of FXR are also involved in gut microbiota. In addition, FXR has various functions in the kidney, adipose tissue, pancreas, cardiovascular system, and tumorigenesis. Consequently, the deregulation of FXR may lead to abnormalities of specific organs and metabolic dysfunction, allowing the protein as an attractive therapeutic target for the management of liver and/or metabolic diseases. Indeed, many FXR agonists have been being developed and are under pre-clinical and clinical investigations. Although obeticholic acid (OCA) is one of the promising candidates, significant safety issues have remained. The effects of FXR modulation might be multifaceted according to tissue specificity, disease type, and/or energy status, suggesting the careful use of FXR agonists. This review summarizes the current knowledge of systemic FXR biology in various organs and the gut⁻liver axis, particularly regarding the recent advancement in these fields, and also provides pharmacological aspects of FXR modulation for rational therapeutic strategies and novel drug development.
Editor: Switzerland: MDPI AG
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Update on FXR Biology: Promising Therapeutic Target?

Han, Chang Yeob

Switzerland: MDPI AG

Buscando em bases de dados remotas. Favor aguardar.