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Serotonin neurons modulate learning rate through uncertainty

Grossman, Cooper D. ; Bari, Bilal A. ; Cohen, Jeremiah Y.

Current biology, 2022-02, Vol.32 (3), p.586-599.e7 [Periódico revisado por pares]

England: Elsevier Inc

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  • Título:
    Serotonin neurons modulate learning rate through uncertainty
  • Autor: Grossman, Cooper D. ; Bari, Bilal A. ; Cohen, Jeremiah Y.
  • Assuntos: Animals ; decision making ; dorsal raphe ; Dorsal Raphe Nucleus - physiology ; learning ; Learning - physiology ; Mice ; Neurons - physiology ; Serotonin ; Uncertainty
  • É parte de: Current biology, 2022-02, Vol.32 (3), p.586-599.e7
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    C.D.G. and B.A.B. collected data. C.D.G., B.A.B., and J.Y.C. designed experiments, analyzed data, and wrote the paper.
    AUTHOR CONTRIBUTIONS
  • Descrição: Regulating how fast to learn is critical for flexible behavior. Learning about the consequences of actions should be slow in stable environments, but accelerate when that environment changes. Recognizing stability and detecting change are difficult in environments with noisy relationships between actions and outcomes. Under these conditions, theories propose that uncertainty can be used to modulate learning rates (“meta-learning”). We show that mice behaving in a dynamic foraging task exhibit choice behavior that varied as a function of two forms of uncertainty estimated from a meta-learning model. The activity of dorsal raphe serotonin neurons tracked both types of uncertainty in the foraging task as well as in a dynamic Pavlovian task. Reversible inhibition of serotonin neurons in the foraging task reproduced changes in learning predicted by a simulated lesion of meta-learning in the model. We thus provide a quantitative link between serotonin neuron activity, learning, and decision making. •Mice demonstrate variable behavioral flexibility during decision making•Flexible behavior can be characterized as meta-learning guided by uncertainty•Serotonin neuron activity correlates with expected and unexpected uncertainty•Reversible inhibition of serotonin neuron activity impairs meta-learning Learning about actions and their outcomes is not a static process and should be adapted to complement the environment. Grossman et al. show evidence of variable learning rates in mice that can be characterized by uncertainty-driven meta-learning and demonstrate a role for serotonin neuron activity in tracking uncertainty to modulate learning.
  • Editor: England: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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