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Sensory disinhibition on passive movement in cervical dystonia

Obermann, Mark ; Vollrath, Clemens ; de Greiff, Armin ; Gizewski, Elke R. ; Diener, Hans-Christoph ; Hallett, Mark ; Maschke, Matthias

Movement disorders, 2010-11, Vol.25 (15), p.2627-2633 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Sensory disinhibition on passive movement in cervical dystonia
Autor: Obermann, Mark ; Vollrath, Clemens ; de Greiff, Armin ; Gizewski, Elke R. ; Diener, Hans-Christoph ; Hallett, Mark ; Maschke, Matthias
Assuntos: Aged ; Biological and medical sciences ; Botulinum Toxins, Type A - therapeutic use ; Brain Mapping ; cervical dystonia ; cortical disinhibition ; Diseases of striated muscles. Neuromuscular diseases ; Female ; fMRI ; focal dystonia ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Motor Cortex - physiopathology ; Movement - physiology ; Movement disorders ; Neurology ; Somatosensory Cortex - physiopathology ; somatosensory system ; Torticollis - physiopathology ; Torticollis - therapy
É parte de: Movement disorders, 2010-11, Vol.25 (15), p.2627-2633
Notas: ark:/67375/WNG-BMFSKPBH-D
ArticleID:MDS23321
Potential conflict of interest: Nothing to report.
istex:47AD29344CA431C77320B05B89F3312534E4BEFE
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Descrição: The relevance of the sensory system in the pathophysiology of cervical dystonia (CD) has been discussed since the description of sensory tricks associated with this disorder. Our objective was to locate changes in somatosensory processing of patients with CD responding in a passive sensory task of body regions that are not affected by dystonic symptoms. We used functional magnetic resonance imaging (fMRI) in 17 patients with CD and 17 healthy controls performing a strictly passive 30‐degree forearm movement task with the left arm. TSUI and TWSTRS rating scales were used for clinical assessment. All patients were treated with botulinum neurotoxin type A (BoNT‐A; Dysport®). Patients with CD showed BOLD‐signal increase in the contralateral primary and secondary sensory cortex, the cingulate cortex and cerebellum bilaterally compared to healthy controls. We found a strong positive correlation of this activation with BoNT‐A dosage in the supplementary motor area (SMA) and a negative correlation with the TWSTRS in that same region. The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor‐system or the direct neuronal representation of the affected dystonic musculature alone. © 2010 Movement Disorder Society
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Sensory disinhibition on passive movement in cervical dystonia

Obermann, Mark ; Vollrath, Clemens ; de Greiff, Armin ; Gizewski, Elke R. ; Diener, Hans-Christoph ; Hallett, Mark ; Maschke, Matthias

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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