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Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish

Abreu, Murilo S ; Giacomini, Ana Cristina V V ; Koakoski, Gessi ; Piato, Angelo L S ; Barcellos, Leonardo J G

PeerJ (San Francisco, CA), 2017-05, Vol.5, p.e3330-e3330, Article e3330 [Periódico revisado por pares]

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Título:
Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish
Autor: Abreu, Murilo S ; Giacomini, Ana Cristina V V ; Koakoski, Gessi ; Piato, Angelo L S ; Barcellos, Leonardo J G
Assuntos: Alarm substance ; Analysis ; Animal behavior ; Aquaculture ; Blood ; Brain research ; Central nervous system ; Cortisol ; Danio rerio ; Fish ; Fisheries and Fish Science ; Fluoxetine ; Hypothalamus ; Neuroscience ; Pharmacology ; Pituitary ; Psychological aspects ; Serotonin ; SSRI ; Stimulants ; Stimuli (Psychology) ; Stress (Psychology) ; Stress response ; Zebra fish ; Zebrafish
É parte de: PeerJ (San Francisco, CA), 2017-05, Vol.5, p.e3330-e3330, Article e3330
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Fluoxetine is a selective serotonin reuptake inhibitor that increases serotonin concentration in the central nervous system and modulates various systems, including the control of sympathetic outflow and the hypothalamus-pituitary-adrenal. However, it is not yet established whether fluoxetine can modulate the responses to stressors stimulants (physical or chemical) that trigger cortisol response in zebrafish. We demonstrate that fluoxetine blunts the response to physical stress, but not to chemical stress.
Editor: United States: PeerJ. Ltd
Idioma: Inglês

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