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Zinc-Enriched Yeast Improves Learning and Memory Impairments in Zinc-Deficient Rats

Zhang, Shuang-Qing ; Zhang, Hai-Bo ; Cheng, Qian ; Zhu, Ya-Min ; Xia, Chang-Hong ; Zhu, Yin-Hong ; Zhang, Yan

Biological trace element research, 2019-05, Vol.189 (1), p.180-185 [Periódico revisado por pares]

New York: Springer US

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Título:
Zinc-Enriched Yeast Improves Learning and Memory Impairments in Zinc-Deficient Rats
Autor: Zhang, Shuang-Qing ; Zhang, Hai-Bo ; Cheng, Qian ; Zhu, Ya-Min ; Xia, Chang-Hong ; Zhu, Yin-Hong ; Zhang, Yan
Assuntos: Animal memory ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Body weight ; Body weight gain ; Brain ; Brain - drug effects ; Brain - metabolism ; Cognition ; Cognitive ability ; Diet ; Dietary Supplements ; Learning ; Learning behaviour ; Life Sciences ; Male ; Maze Learning - drug effects ; Memory ; Memory - drug effects ; Memory Disorders - blood ; Memory Disorders - metabolism ; Nutrient deficiency ; Nutrition ; Oncology ; Oral administration ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Rodents ; Supplementation ; Weight gain ; Yeast ; Yeast, Dried ; Yeasts ; Zinc ; Zinc - blood ; Zinc - pharmacology
É parte de: Biological trace element research, 2019-05, Vol.189 (1), p.180-185
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Zinc (Zn) highly concentrates in the brain and plays a key role in memory formation and learning processes. Zn deficiency results in cognitive impairments, memory deficits, alterations of neuropsychological behavior, and motor development. Although Zn-enriched yeast (ZnY) is widely used for dietary fortification and supplementation of Zn, the effect of ZnY on cognition still remains unclear. The purpose of the study was to investigate the effect of ZnY on behavior in Zn-deficient and Zn-sufficient rats. Three-week-old rats were fed low Zn diets for 145 days to establish Zn-deficient rats. ZnY was orally administered to Zn-deficient rats at three dose levels of 1, 2, and 4 mg Zn/kg/day for 55 days. Rat appearance, body weight, plasma and brain Zn, Morris water maze test, and step-through passive avoidance test were observed. Compared to Zn-sufficient rats, body weight gain, plasma zinc level, resident time, and step-through time in Zn-deficient rats were significantly lower. Zn deficiency impaired functions of learning and memory, while ZnY as a plausible therapeutic intervention alleviated the cognitive impairments caused by Zn deficiency.
Editor: New York: Springer US
Idioma: Inglês

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Zinc-Enriched Yeast Improves Learning and Memory Impairments in Zinc-Deficient Rats

Zhang, Shuang-Qing ; Zhang, Hai-Bo ; Cheng, Qian ; Zhu, Ya-Min ; Xia, Chang-Hong ; Zhu, Yin-Hong ; Zhang, Yan

New York: Springer US

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