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Correlation between Hepatitis B surface antigen titers and HBV DNA levels

Alghamdi, Amal ; Aref, Nagwa ; El-Hazmi, Malak ; Al-Hamoudi, Waleed ; Alswat, Khalid ; Helmy, Ahmed ; Sanai, Faisal ; Abdo, Ayman

Saudi journal of gastroenterology, 2013-11, Vol.19 (6), p.252-257 [Periódico revisado por pares]

India: Medknow Publications

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Título:
Correlation between Hepatitis B surface antigen titers and HBV DNA levels
Autor: Alghamdi, Amal ; Aref, Nagwa ; El-Hazmi, Malak ; Al-Hamoudi, Waleed ; Alswat, Khalid ; Helmy, Ahmed ; Sanai, Faisal ; Abdo, Ayman
Assuntos: Adult ; Aged ; Care and treatment ; Carrier State ; Deoxyribonucleic acid ; Development and progression ; DNA ; DNA, Viral - genetics ; Drug therapy ; Female ; Genetic aspects ; Genotype ; Genotype & phenotype ; Genotype D ; HBeAg negative ; HBV DNA ; Health aspects ; Hepatitis ; Hepatitis B ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B virus - immunology ; Hepatitis B, Chronic - virology ; Humans ; inactive carrier ; Infections ; Liver cirrhosis ; Liver diseases ; Male ; Middle Aged ; Original ; Patient satisfaction ; Physiological aspects ; Polymerase chain reaction ; quantitative HBsAg ; Real-Time Polymerase Chain Reaction ; Saudi Arabia ; Studies ; Young Adult
É parte de: Saudi journal of gastroenterology, 2013-11, Vol.19 (6), p.252-257
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Background/Aim: To assess the correlation between serum HBsAg titers and hepatitis B virus (HBV) DNA levels in patients with hepatitis B envelop antigen-negative (HBeAg −ve) HBV genotype-D (HBV/D) infection. Patients and Methods: A total of 106 treatment- naïve, HBeAg −ve HBV/D patients were included; 78 in the inactive carrier (IC) state and 28 in the active hepatitis (AH) stage. HBV DNA load and HBsAg titers were tested using TaqMan real-time polymerase chain reaction (PCR) and automated chemiluminescent microparticle immunoassay, respectively. Results: The median (range) log10 HBsAg titer was significantly lower in the IC group compared with AH group, 3.09 (−1 to -4.4) versus 3.68 (−0.77 to 5.09) IU/mL, respectively; P < 0.001. The suggested cutoff value of HBsAg titer to differentiate between the two groups was 3.79 log10 IU/mL. In addition, there was a significant positive correlation between HBsAg and HBV DNA levels in the whole cohort, AH, and IC groups (r = 0.6, P < 0.0001; r = 0.591, P = 0.001; and r = 0.243, P = 0.032, respectively). Conclusion: Serum HBsAg titers may correlate with HBV DNA in treatment-naïve HBeAg -ve HBV/D patients, and supports the use of HBsAg levels in clinical practice as a predictor of serum HBV DNA levels.
Editor: India: Medknow Publications
Idioma: Inglês

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Correlation between Hepatitis B surface antigen titers and HBV DNA levels

Alghamdi, Amal ; Aref, Nagwa ; El-Hazmi, Malak ; Al-Hamoudi, Waleed ; Alswat, Khalid ; Helmy, Ahmed ; Sanai, Faisal ; Abdo, Ayman

India: Medknow Publications

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