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DNA topology

Andrew D Bates Anthony Maxwell

Oxford IRL Press at Oxford University Press New York c1993

Localização: CQ - Conjunto das Químicas    (574.873282 B329d )(Acessar)

  • Título:
    DNA topology
  • Autor: Andrew D Bates
  • Anthony Maxwell
  • Assuntos: DNA -- Conformation; DNA -- physiology; DNA (ESTRUTURA); DNA
  • Notas: Includes bibliographical references and index
  • Descrição: DNA structure -- Watson-Crick model -- B-form DNA -- A-form DNA -- Z-form DNA -- Alternative DNA structures -- Cruciforms and Holliday junctions -- H-DNA -- Intrinsic curvature and DNA bending -- Intrinsic curvature -- DNA flexibility -- DNA supercoiling -- Historical perspective -- Closed-circular DNA and supercoiling -- Quantitative measure of DNA supercoiling -- Linking number -- Supercoiling, linking difference, and specific linking difference -- Geometric properties of closed-circular DNA -- Twist and writhe -- Interconversion of twist and writhe -- Nomenclature -- Topology and geometry of real DNA -- Agarose gel electrophoresis of plasmids -- Relaxation with topoisomerases -- Effect of intercalators -- Effect of protein binding -- Thermodynamics of DNA supercoiling -- Ethidium bromide titration -- Gaussian distribution of topoisomers -- Effect of DNA circle size -- Supercoiling in small DNA circles -- Biological effects of supercoiling free energy -- DNA on surfaces -- Helical repeat of DNA -- Surface linking treatment -- DNA winding number -- Surface linking number -- Interwound supercoiled DNA. (cont) Nucleosome -- Linking difference and the linking number paradox -- Early resolution of the linking number paradox -- Helical repeat at the nucleosome surface -- Measurements of hs for the nucleosome -- Topology and geometry of DNA in the nucleosome -- Knots and catenanes -- Knots -- Occcurrence of knots -- Description of knots -- Catenanes --
    Occurrence of catenanes -- Description of catenanes -- Knots and catenanes as probes of DNA: protein interactions -- DNA topoisomerases -- Reactions of topoisomerases -- Mechanisms of topoisomerases -- Topoisomerases as drug targets -- Biological role of topoisomerases -- Biological consequences of DNA topology -- Introduction: the ubiquity of DNA supercoiling -- General biological consequences of negative supercoiling -- Genome organization -- Eukaryotes -- Prokaryotes -- Transcription: the twin supercoiled domain model -- New role for topoisomerases -- Control of gene expression -- RNA polymerase binding -- Transcriptional regulatory proteins -- Replication -- Replication initiation -- Replication elongation -- Termination of replication. (cont) Recombination -- Bacteriophage [gamma] Int protein -- Resolvase
  • Títulos relacionados: Série:In focus (Oxford, England)
  • Editor: Oxford IRL Press at Oxford University Press New York
  • Data de criação/publicação: c1993
  • Formato: xii, 114 p ill. (some col.) 23 cm.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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