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Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

Grenadyorov, A.S. ; Zhulkov, M.O. ; Solovyev, А.А. ; Oskomov, K.V. ; Semenov, V.A. ; Chernyavskiy, A.M. ; Sirota, D.A. ; Karmadonova, N.A. ; Malashchenko, V.V. ; Litvinova, L.S. ; Khaziakhmatova, O.G. ; Gazatova, N.D. ; Khlusov, I.A.

Materials Science & Engineering C, 2021-04, Vol.123, p.112002-112002, Article 112002

Lausanne: Elsevier B.V

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Título:
Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy
Autor: Grenadyorov, A.S. ; Zhulkov, M.O. ; Solovyev, А.А. ; Oskomov, K.V. ; Semenov, V.A. ; Chernyavskiy, A.M. ; Sirota, D.A. ; Karmadonova, N.A. ; Malashchenko, V.V. ; Litvinova, L.S. ; Khaziakhmatova, O.G. ; Gazatova, N.D. ; Khlusov, I.A.
Assuntos: a-C:H:SiOx coating ; Alloys ; Aorta ; Argon ; Bacterial corrosion ; Bias ; Biocompatibility ; Blood ; Buffers ; Chemical vapor deposition ; Coatings ; Coronary vessels ; Corrosion ; Corrosion currents ; Corrosion rate ; Corrosion resistance ; Corrosion resistant alloys ; Current density ; Cytokines ; Cytotoxicity ; Hydrocarbons ; Inflammation ; Interferon ; Interleukin 1 receptor antagonist ; Interleukin 1 receptors ; Interleukin 12 ; Interleukin 15 ; Interleukin 17 ; Interleukin 6 ; Interleukins ; Leukocytes (mononuclear) ; Materials science ; PACVD ; Protective coatings ; Pumps ; Sodium chloride ; Substrates ; Support systems ; Surface properties ; Surgical implants ; Thorax ; Thromboembolism ; Thrombosis ; Titanium ; Titanium base alloys ; Toxicity ; Transplants & implants ; Tumor necrosis factor-α ; Vapors
É parte de: Materials Science & Engineering C, 2021-04, Vol.123, p.112002-112002, Article 112002
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems. [Display omitted] •The a-C:H:SiOx coating improves the corrosion resistance of Ti6Al4V titanium alloy.•The a-C:H:SiOx coating deposition provides a negative electrostatic potential for the surface.•The a-C:H:SiOx coating facilitates endothelization of implants in thoracic aorta.•The a-C:H:SiOx coating reduces pro-inflammatory interleukin secretion.•The coating elevates the concentration of anti-inflammatory interleukin IL-1Ra.
Editor: Lausanne: Elsevier B.V
Idioma: Inglês

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Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

Grenadyorov, A.S. ; Zhulkov, M.O. ; Solovyev, А.А. ; Oskomov, K.V. ; Semenov, V.A. ; Chernyavskiy, A.M. ; Sirota, D.A. ; Karmadonova, N.A. ; Malashchenko, V.V. ; Litvinova, L.S. ; Khaziakhmatova, O.G. ; Gazatova, N.D. ; Khlusov, I.A.

Lausanne: Elsevier B.V

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