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Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Terranova, Joseph I. ; Yokose, Jun ; Osanai, Hisayuki ; Marks, William D. ; Yamamoto, Jun ; Ogawa, Sachie K. ; Kitamura, Takashi

Neuron (Cambridge, Mass.), 2022-04, Vol.110 (8), p.1416-1431.e13 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Hippocampal-amygdala memory circuits govern experience-dependent observational fear
  • Autor: Terranova, Joseph I. ; Yokose, Jun ; Osanai, Hisayuki ; Marks, William D. ; Yamamoto, Jun ; Ogawa, Sachie K. ; Kitamura, Takashi
  • Assuntos: amygdala ; Amygdala - physiology ; Animals ; anterior cingulate cortex ; Basolateral Nuclear Complex - physiology ; contextual fear conditioning ; emotional empathy ; Fear - physiology ; Gyrus Cinguli ; hippocampus ; Hippocampus - physiology ; memory engram cells ; Mice ; observational fear ; perception-action coupling ; social memory
  • É parte de: Neuron (Cambridge, Mass.), 2022-04, Vol.110 (8), p.1416-1431.e13
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    J.T., and T.K., contributed to the study design. J.T., J.Yo., and H.O. conducted the surgeries, behavior, and histological experiments. W.M conducted ex vivo electrophysiology experiments. J.T conducted in vivo calcium imaging experiments. J.Yo conducted the AAV production. J.T, J.Yo., H.O., W.M., J.Ya., S.O., and T.K., contributed to the interpretation for data analyses. J.T., and T.K., wrote the paper. All authors approved the final manuscript.
    Author Contributions
  • Descrição: The empathic ability to vicariously experience the other’s fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior similar fear experience in the observer and social familiarity with the demonstrator. However, the neural circuit mechanisms of experience-dependent OF (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits in mice without involving the anterior cingulate cortex, considered a center of OF, mediate Exp OF. Dorsal HPC neurons generate fear memory engram cells in BLA encoding prior similar fear experiences, which are essential for Exp OF. On the other hand, ventral HPC neurons respond to the familiar demonstrator’s aversive situation during Exp OF, which reactivates the fear memory engram cells in BLA to elicit Exp OF. Our study provides new insights into the memory engram-dependent perception-action coupling that underlies empathic behaviors like Exp OF. [Display omitted] •Hippocampus and amygdala mediate experience-dependent observational fear (Exp OF)•Exp OF requires fear memory engram cells encoding prior similar fear experiences•The dorsal hippocampus generates memory engram cells in the basolateral amygdala (BLA)•The ventral hippocampus reactivates memory engram cells in BLA to facilitate Exp OF How do prior similar experiences and social familiarity with the demonstrator facilitate observational fear? In this study, Terranova et al. find that memory engram circuits in the hippocampal-amygdala networks encoding prior experiences integrate a perception-action coupling for experience-dependent enhancement of observational fear.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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