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2-[ 18 F]-FDG PET/CT Semiquantitative and Radiomics Predictive Parameters of Richter's Transformation in CLL Patients

Albano, Domenico ; Calabrò, Anna ; Dondi, Francesco ; Bertagna, Francesco

Medicina (Kaunas, Lithuania), 2024-01, Vol.60 (2), p.203 [Periódico revisado por pares]

Switzerland: MDPI AG

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  • Título:
    2-[ 18 F]-FDG PET/CT Semiquantitative and Radiomics Predictive Parameters of Richter's Transformation in CLL Patients
  • Autor: Albano, Domenico ; Calabrò, Anna ; Dondi, Francesco ; Bertagna, Francesco
  • Assuntos: 18F-FDG ; Biopsy ; Blood ; CLL ; Fluorodeoxyglucose F18 ; Humans ; Leukemia ; Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging ; Lymphatic system ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse ; Medical imaging ; Metabolism ; Patients ; PET/CT ; Positron Emission Tomography Computed Tomography - methods ; Prognosis ; Radiomics ; Radiopharmaceuticals ; Retrospective Studies ; Richter transformation ; Tomography
  • É parte de: Medicina (Kaunas, Lithuania), 2024-01, Vol.60 (2), p.203
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: : Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in developed countries, which can evolve into aggressive lymphoma variants, a process called Richter transformation (RT). The aim of this retrospective study was to analyze the role of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (2-[18F]-FDG PET/CT) and its semiquantitative and radiomics features in detecting RT and evaluate the impact on overall survival (OS). : One hundred and thirty-seven patients with histologically proven CLL were retrospectively recruited. PET/CT images were qualitatively and semiquantitatively examined by estimating the main metabolic parameters (the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), lesion-to-blood-pool SUV ratio (L-BP SUV R), lesion-to-liver SUV ratio (L-L SUV R), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and radiomics first- and second- order variables of the lesion with highest uptake. The role of these parameters in predicting RT and OS was analyzed. : One hundred and thirty (95%) PET/CT scans were positive, showing an increased tracer uptake at the site of disease, whereas the remaining 7 (5%) scans were negative. SUVbw, SUVlbm, SUVbsa, L-L SUV ratio, and L-BP SUV ratio were significantly higher in the RT group ( < 0.001 in all cases). Radiomics first- and second-order features were not significantly associated with RT. After a median follow-up of 44 months, 56 patients died; OS was significantly shorter in patients with RT than patients without RT (28 vs. 34 months; = 0.002). Binet-stage, RT, and L-BP SUV R were shown to be independent prognostic features. : Semiquantitative PET/CT parameters such as SUVbw, SUVlbm, SUVbsa, L-L SUV ratio and L-BP SUV ratio may be useful in discriminating patients with a high risk of developing RT, whereas Binet-stage, RT, and L-BP SUV R are also significant in predicting OS.
  • Editor: Switzerland: MDPI AG
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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