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Targeted chemoradiation for advanced head and neck cancer: Analysis of 213 patients

Robbins, K. Thomas ; Kumar, Parves ; Wong, Frank S. H. ; Hartsell, William F. ; Flick, Pamela ; Palmer, Robert ; Weir III, Alva B. ; Neill, H. Barry ; Murry, Thomas ; Ferguson, Robert ; Hanchett, Catherine ; Vieira, Francisco ; Bush, Andrew ; Howell, Stephen B.

Head & neck, 2000-10, Vol.22 (7), p.687-693 [Periódico revisado por pares]

New York: John Wiley & Sons, Inc

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Título:
Targeted chemoradiation for advanced head and neck cancer: Analysis of 213 patients
Autor: Robbins, K. Thomas ; Kumar, Parves ; Wong, Frank S. H. ; Hartsell, William F. ; Flick, Pamela ; Palmer, Robert ; Weir III, Alva B. ; Neill, H. Barry ; Murry, Thomas ; Ferguson, Robert ; Hanchett, Catherine ; Vieira, Francisco ; Bush, Andrew ; Howell, Stephen B.
Assuntos: Adult ; Aged ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - radiotherapy ; chemoradiation ; Cisplatin - adverse effects ; Cisplatin - therapeutic use ; Combined Modality Therapy ; Diseases of the upper aerodigestive tract ; Ent and stomatology ; Female ; head and neck cancer ; Head and Neck Neoplasms - drug therapy ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - radiotherapy ; Humans ; Infusions, Intra-Arterial ; Infusions, Intravenous ; intra-arterial ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Radiation-Sensitizing Agents - adverse effects ; Radiation-Sensitizing Agents - therapeutic use ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Survival Rate ; Thiosulfates - therapeutic use ; Tumors
É parte de: Head & neck, 2000-10, Vol.22 (7), p.687-693
Notas: Baptist Memorial Health Care Foundation
istex:5BF273BFFD334334BF3CC9D2D525DF727CBD2481
Clayton Foundation for Research, California Division
ark:/67375/WNG-54S3C9DB-N
ArticleID:HED8
Descrição: Background To determine the survival results, patterns of relapse, and organ preservation effects of a targeted chemoradiation protocol for patients with advanced (stage III–IV) carcinoma of the head and neck. Methods Analysis of 213 patients with stage III–IV squamous cell carcinoma treated at UT Memphis between June 1993 and March 1998. Treatment included weekly intra‐arterial infusions of cisplatin (150 mg/m2/ week × 4) rapidly delivered to the tumor bulk, simultaneous intravenous thiosulfate for systemic drug neutralization, and conventional external‐beam irradiation (180–200 cGy/fraction) to a total dose of 68–72 Gy. Results Tumor response, toxicity, disease control above the clavicle, pattern of relapse, and survival. There were 89 events of grade III–IV toxicity and 6 treatment‐related deaths (grade V). Complete response in the primary and regional sites was obtained in 171 of 213 (80%) and 92 of 151 (61%), respectively. The rate of clearance of regional disease after neck dissection was 98%. There were 51 of 195 recurrences (26%): 11 local (5.6%), 5 regional (2.6%), and 35 distant (17.9%). The Kaplan Meier plot projections for overall and cancer‐related 5‐year survival was 38.8% and 53.6%, respectively, whereas disease control above the clavicle was 74.3%. Conclusions We believe this chemoradiation protocol represents an effective management scheme for patients with advanced head and neck cancer with a high rate of organ preservation and possibly improved survival. © 2000 John Wiley & Sons, Inc. Head Neck 22: 687–693, 2000.
Editor: New York: John Wiley & Sons, Inc
Idioma: Inglês

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Targeted chemoradiation for advanced head and neck cancer: Analysis of 213 patients

Robbins, K. Thomas ; Kumar, Parves ; Wong, Frank S. H. ; Hartsell, William F. ; Flick, Pamela ; Palmer, Robert ; Weir III, Alva B. ; Neill, H. Barry ; Murry, Thomas ; Ferguson, Robert ; Hanchett, Catherine ; Vieira, Francisco ; Bush, Andrew ; Howell, Stephen B.

New York: John Wiley & Sons, Inc

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