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Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment

Cohen, Tehila ; Shomron, Noam

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12908 [Periódico revisado por pares]

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Título:
Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment
Autor: Cohen, Tehila ; Shomron, Noam
Assuntos: Brain research ; Drug therapy ; Gene expression ; Genetic transcription ; Memory ; MicroRNA ; MicroRNAs ; Post traumatic stress disorder ; PTSD ; Review ; RNA ; transcription
É parte de: International journal of molecular sciences, 2023-08, Vol.24 (16), p.12908
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically, we examine the effects of time and location on gene expression alterations. We then discuss the potential for harnessing these alterations to modulate memories, particularly fear memories, to alleviate post-traumatic stress disorder (PTSD) symptoms. The current state of research suggests that transcriptional changes play a major role in memory modulation and targeting them through microRNAs may hold promise as a novel approach for treating memory-related disorders such as PTSD.
Editor: Basel: MDPI AG
Idioma: Inglês

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