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Esophageal manometry in systemic sclerosis: findings and association with clinical manifestations

Markus, Juliana ; Pinto, Rogério de Melo Costa ; Matoso, Abadia Gilda Buso ; Ranza, Roberto

Revista da Associacao Medica Brasileira (1992), 2020, Vol.66 (1), p.48-54 [Periódico revisado por pares]

Brazil

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Título:
Esophageal manometry in systemic sclerosis: findings and association with clinical manifestations
Autor: Markus, Juliana ; Pinto, Rogério de Melo Costa ; Matoso, Abadia Gilda Buso ; Ranza, Roberto
Assuntos: Adult ; Aged ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Esophageal Motility Disorders - complications ; Esophageal Motility Disorders - diagnostic imaging ; Esophageal Motility Disorders - physiopathology ; Esophageal Sphincter, Lower - pathology ; Esophageal Sphincter, Lower - physiopathology ; Esophagus - diagnostic imaging ; Esophagus - pathology ; Esophagus - physiopathology ; Female ; Hemagglutination ; Humans ; Lung Diseases, Interstitial - complications ; Lung Diseases, Interstitial - diagnostic imaging ; Lung Diseases, Interstitial - physiopathology ; Male ; Manometry - methods ; Middle Aged ; Scleroderma, Systemic - complications ; Scleroderma, Systemic - diagnostic imaging ; Scleroderma, Systemic - physiopathology ; Tomography, X-Ray Computed - methods
É parte de: Revista da Associacao Medica Brasileira (1992), 2020, Vol.66 (1), p.48-54
Descrição: Systemic sclerosis (SSC) is an autoimmune disorder that affects several organs of unknown etiology, characterized by vascular damage and fibrosis of the skin and organs. Among the organs involved are the esophagus and the lung. To relate the profile of changes in esophageal electromanometry (EM), the profile of skin involvement, interstitial pneumopathy (ILD), and esophageal symptoms in SSC patients. This is an observational, cross-sectional study carried out at the SSC outpatient clinic of the Hospital de Clínicas of the Federal University of Uberlândia. After approval by the Ethics Committee and signed the terms of consent, 50 patients were initially enrolled, from 04/12/2014 to 06/25/2015. They were submitted to the usual investigations according to the clinical picture. The statistical analysis was descriptive in percentage, means, and standard deviation. The Chi-square test was used to evaluate the relationship between EM, high-resolution tomography, and esophageal symptoms. 91.9% of the patients had some manometric alterations. 37.8% had involvement of the esophageal body and lower esophageal sphincter. 37.8% had ILD. 24.3% presented the diffuse form of SSC. No association was found between manometric changes and clinical manifestations (cutaneous, pulmonary, and gastrointestinal symptoms). The present study confirms that esophageal motility alterations detected by EM are frequent in SSC patients, but may not be related to cutaneous extension involvement, the presence of ILD, or the gastrointestinal complaints of patients.
Editor: Brazil
Idioma: Inglês

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Esophageal manometry in systemic sclerosis: findings and association with clinical manifestations

Markus, Juliana ; Pinto, Rogério de Melo Costa ; Matoso, Abadia Gilda Buso ; Ranza, Roberto

Brazil

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