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12-h clock regulation of genetic information flow by XBP1s

Pan, Yinghong ; Ballance, Heather ; Meng, Huan ; Gonzalez, Naomi ; Kim, Sam-Moon ; Abdurehman, Leymaan ; York, Brian ; Chen, Xi ; Schnytzer, Yisrael ; Levy, Oren ; Dacso, Clifford C ; McClung, Colleen A ; O'Malley, Bert W ; Liu, Silvia ; Zhu, Bokai Kramer, Achim

PLoS biology, 2020-01, Vol.18 (1), p.e3000580-e3000580 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
12-h clock regulation of genetic information flow by XBP1s
Autor: Pan, Yinghong ; Ballance, Heather ; Meng, Huan ; Gonzalez, Naomi ; Kim, Sam-Moon ; Abdurehman, Leymaan ; York, Brian ; Chen, Xi ; Schnytzer, Yisrael ; Levy, Oren ; Dacso, Clifford C ; McClung, Colleen A ; O'Malley, Bert W ; Liu, Silvia ; Zhu, Bokai
Kramer, Achim
Assuntos: Activating transcription factor 1 ; Aging ; Animals ; Binding sites ; Biological clocks ; Biological Clocks - genetics ; Biological rhythms ; Biology and Life Sciences ; Cells, Cultured ; Cellular biology ; Circadian rhythm ; Circadian Rhythm - genetics ; Circadian rhythms ; Eigen values ; Eigenvalues ; Endoplasmic reticulum ; Funding ; Gene expression ; Gene Expression Regulation - genetics ; Gene regulation ; Gene Regulatory Networks - genetics ; Golgi apparatus ; Hypotheses ; Information flow ; Life sciences ; Liver ; Liver - metabolism ; Male ; Mammals ; Marine animals ; Marine organisms ; Medical schools ; Medicine ; Metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; mRNA processing ; Neurosciences ; Organ Specificity - genetics ; Pathways ; Physical Sciences ; Protein Isoforms - genetics ; Protein Isoforms - physiology ; Protein transport ; Proteins ; Software ; Temporal variations ; Time Factors ; Transcription ; Transcription, Genetic ; Translation initiation ; Ultradian Rhythm - genetics ; X-Box Binding Protein 1 - genetics ; X-Box Binding Protein 1 - physiology
É parte de: PLoS biology, 2020-01, Vol.18 (1), p.e3000580-e3000580
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Current address: Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America
The authors have declared that no competing interests exist.
Descrição: Our group recently characterized a cell-autonomous mammalian 12-h clock independent from the circadian clock, but its function and mechanism of regulation remain poorly understood. Here, we show that in mouse liver, transcriptional regulation significantly contributes to the establishment of 12-h rhythms of mRNA expression in a manner dependent on Spliced Form of X-box Binding Protein 1 (XBP1s). Mechanistically, the motif stringency of XBP1s promoter binding sites dictates XBP1s's ability to drive 12-h rhythms of nascent mRNA transcription at dawn and dusk, which are enriched for basal transcription regulation, mRNA processing and export, ribosome biogenesis, translation initiation, and protein processing/sorting in the Endoplasmic Reticulum (ER)-Golgi in a temporal order consistent with the progressive molecular processing sequence described by the central dogma information flow (CEDIF). We further identified GA-binding proteins (GABPs) as putative novel transcriptional regulators driving 12-h rhythms of gene expression with more diverse phases. These 12-h rhythms of gene expression are cell autonomous and evolutionarily conserved in marine animals possessing a circatidal clock. Our results demonstrate an evolutionarily conserved, intricate network of transcriptional control of the mammalian 12-h clock that mediates diverse biological pathways. We speculate that the 12-h clock is coopted to accommodate elevated gene expression and processing in mammals at the two rush hours, with the particular genes processed at each rush hour regulated by the circadian and/or tissue-specific pathways.
Editor: United States: Public Library of Science
Idioma: Inglês

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12-h clock regulation of genetic information flow by XBP1s

Pan, Yinghong ; Ballance, Heather ; Meng, Huan ; Gonzalez, Naomi ; Kim, Sam-Moon ; Abdurehman, Leymaan ; York, Brian ; Chen, Xi ; Schnytzer, Yisrael ; Levy, Oren ; Dacso, Clifford C ; McClung, Colleen A ; O'Malley, Bert W ; Liu, Silvia ; Zhu, Bokai Kramer, Achim

United States: Public Library of Science

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