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Recent progress in broadly neutralizing antibodies to HIV

Sok, Devin ; Burton, Dennis R

Nature immunology, 2018-11, Vol.19 (11), p.1179-1188 [Periódico revisado por pares]

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Título:
Recent progress in broadly neutralizing antibodies to HIV
Autor: Sok, Devin ; Burton, Dennis R
Assuntos: AIDS vaccines ; AIDS Vaccines - immunology ; Animal models ; Animals ; Antibodies ; Antibodies, Neutralizing - immunology ; Care and treatment ; Data processing ; HIV ; HIV Antibodies - immunology ; HIV infection ; HIV infections ; HIV Infections - immunology ; Human immunodeficiency virus ; Humans ; Immunoglobulins ; Neutralizing ; Prophylaxis ; Vaccines ; Viral antibodies
É parte de: Nature immunology, 2018-11, Vol.19 (11), p.1179-1188
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
Descrição: In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); i.e., antibodies able to neutralize diverse isolates of HIV. We consider the characterization of novel bnAbs, recent data on the effects of bnAbs in vivo in humans and animal models, and the importance of both kinds of data for the application of Abs to prophylaxis and therapy and to guide vaccine design. We seek to place newly discovered bnAbs in the context of existing bnAbs, and we explore the various characteristics of the antibodies that are most desirable for different applications.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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