Idioma:

Integrin activation

Ginsberg, Mark H

BMB Reports, 2014, 47(12), , pp.655-659 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por

Título:
Integrin activation
Autor: Ginsberg, Mark H
Assuntos: Allosteric Regulation ; Cell Adhesion ; Humans ; Integrins - chemistry ; Integrins - metabolism ; Invited Mini Review ; Protein Binding ; Protein Structure, Tertiary ; Talin - chemistry ; Talin - metabolism ; 화학
É parte de: BMB Reports, 2014, 47(12), , pp.655-659
Notas: KISTI1.1003/JNL.JAKO201402148670054
G704-SER000001672.2014.47.12.006
Descrição: Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate. Conversely, cells can modulate the affinity of integrins for their ligands a process operationally defined as integrin activation. Analysis of activation of integrins has now provided a detailed molecular understanding of this unique form of "inside-out" signal transduction and revealed new paradigms of how transmembrane domains (TMD) can transmit long range allosteric changes in transmembrane proteins. Here, we will review how talin and mediates integrin activation and how the integrin TMD can transmit these inside out signals.
Editor: Korea (South): Korean Society for Biochemistry and Molecular Biology
Idioma: Inglês;Coreano

Links

Voltar para lista de resultados