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Dating the Origin of the CCR5-Δ 32 AIDS-Resistance Allele by the Coalescence of Haplotypes

Stephens, J. Claiborne ; Reich, David E. ; Goldstein, David B. ; Shin, Hyoung Doo ; Smith, Michael W. ; Carrington, Mary ; Winkler, Cheryl ; Huttley, Gavin A. ; Allikmets, Rando ; Schriml, Lynn ; Gerrard, Bernard ; Malasky, Michael ; Ramos, Maria D. ; Morlot, Susanne ; Tzetis, Maria ; Oddoux, Carole ; di Giovine, Francesco S. ; Nasioulas, Georgios ; Chandler, David ; Aseev, Michael ; Hanson, Matthew ; Kalaydjieva, Luba ; Glavac, Damjan ; Gasparini, Paolo ; Kanavakis, E. ; Claustres, Mireille ; Kambouris, Marios ; Ostrer, Harry ; Duff, Gordon ; Baranov, Vladislav ; Sibul, Hiljar ; Metspalu, Andres ; Goldman, David ; Martin, Nick ; Duffy, David ; Schmidtke, Jorg ; Estivill, Xavier ; O'Brien, Stephen J. ; Dean, Michael

American journal of human genetics, 1998-06, Vol.62 (6), p.1507-1515 [Periódico revisado por pares]

Elsevier Inc

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Título:
Dating the Origin of the CCR5-Δ 32 AIDS-Resistance Allele by the Coalescence of Haplotypes
Autor: Stephens, J. Claiborne ; Reich, David E. ; Goldstein, David B. ; Shin, Hyoung Doo ; Smith, Michael W. ; Carrington, Mary ; Winkler, Cheryl ; Huttley, Gavin A. ; Allikmets, Rando ; Schriml, Lynn ; Gerrard, Bernard ; Malasky, Michael ; Ramos, Maria D. ; Morlot, Susanne ; Tzetis, Maria ; Oddoux, Carole ; di Giovine, Francesco S. ; Nasioulas, Georgios ; Chandler, David ; Aseev, Michael ; Hanson, Matthew ; Kalaydjieva, Luba ; Glavac, Damjan ; Gasparini, Paolo ; Kanavakis, E. ; Claustres, Mireille ; Kambouris, Marios ; Ostrer, Harry ; Duff, Gordon ; Baranov, Vladislav ; Sibul, Hiljar ; Metspalu, Andres ; Goldman, David ; Martin, Nick ; Duffy, David ; Schmidtke, Jorg ; Estivill, Xavier ; O'Brien, Stephen J. ; Dean, Michael
Assuntos: AIDS resistance ; Ancestral haplotype ; Coalescence of haplotypes ; Phylogenetic analysis ; Short tandem-repeat polymorphism
É parte de: American journal of human genetics, 1998-06, Vol.62 (6), p.1507-1515
Descrição: The CCR5-Δ 32 deletion obliterates the CCR5 chemokine and the human immunodeficiency virus (HIV)–1 coreceptor on lymphoid cells, leading to strong resistance against HIV-1 infection and AIDS. A genotype survey of 4,166 individuals revealed a cline of CCR5-Δ 32 allele frequencies of 0%–14% across Eurasia, whereas the variant is absent among native African, American Indian, and East Asian ethnic groups. Haplotype analysis of 192 Caucasian chromosomes revealed strong linkage disequilibrium between CCR5 and two microsatellite loci. By use of coalescence theory to interpret modern haplotype genealogy, we estimate the origin of the CCR5-Δ 32–containing ancestral haplotype to be ∼700 years ago, with an estimated range of 275–1,875 years. The geographic cline of CCR5-Δ 32 frequencies and its recent emergence are consistent with a historic strong selective event (e.g., an epidemic of a pathogen that, like HIV-1, utilizes CCR5), driving its frequency upward in ancestral Caucasian populations.
Editor: Elsevier Inc
Idioma: Inglês

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Dating the Origin of the CCR5-Δ 32 AIDS-Resistance Allele by the Coalescence of Haplotypes

Elsevier Inc

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