Idioma:

Prognostic factors in de novo metastatic renal cell carcinoma : A report from the latin american renal cancer group

Abreu, Diego ; Carvalhal, Gustavo ; Gueglio, Guillermo ; Tobía González, Ignacio Pablo ; Garcia, Patricio ; Zuñiga, Alvaro ; Meza, Luis ; Bengió, Rubén ; Scorticati, Carlos H ; Castillejos, Ricardo ; Rodriguez, Francisco ; Autran Gómez, Ana María ; González Enguita, María del Carmen ; Gadú Campos-Salcedo, Jose ; Nolazco, Alejandro ; Ameri, Carlos Alberto ; Zampolli, Hamilton Campos ; Langenhin, Raúl ; Muguruza, Diego ; Tobias-Machado, Marcos ; Mingote, Pablo ; Yandian, Juan ; Clavijo, Jorge ; Nogueira, Lucas ; Clark, Omar ; Secin, Fernando ; Rovegno, Agustín Roberto ; Vilas, Ana ; Barrios, Enrique ; Decia, Ricardo ; Guimarães, Gustavo ; Glina, Sidney ; Pal, Sumanta K ; Rodríguez, Óscar ; Palou, Juan ; Spiess, Philippe ; Lara, Primo Nery ; Marston Linehan, W ; Pastore, Antonio Luigi ; Zequi, Stênio de Cássio

2021

Texto completo disponível

Citações Citado por

Enviar para

Título:
Prognostic factors in de novo metastatic renal cell carcinoma : A report from the latin american renal cancer group
Autor: Abreu, Diego ; Carvalhal, Gustavo ; Gueglio, Guillermo ; Tobía González, Ignacio Pablo ; Garcia, Patricio ; Zuñiga, Alvaro ; Meza, Luis ; Bengió, Rubén ; Scorticati, Carlos H ; Castillejos, Ricardo ; Rodriguez, Francisco ; Autran Gómez, Ana María ; González Enguita, María del Carmen ; Gadú Campos-Salcedo, Jose ; Nolazco, Alejandro ; Ameri, Carlos Alberto ; Zampolli, Hamilton Campos ; Langenhin, Raúl ; Muguruza, Diego ; Tobias-Machado, Marcos ; Mingote, Pablo ; Yandian, Juan ; Clavijo, Jorge ; Nogueira, Lucas ; Clark, Omar ; Secin, Fernando ; Rovegno, Agustín Roberto ; Vilas, Ana ; Barrios, Enrique ; Decia, Ricardo ; Guimarães, Gustavo ; Glina, Sidney ; Pal, Sumanta K ; Rodríguez, Óscar ; Palou, Juan ; Spiess, Philippe ; Lara, Primo Nery ; Marston Linehan, W ; Pastore, Antonio Luigi ; Zequi, Stênio de Cássio
Assuntos: Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; Latin America ; Prognosis ; Treatment Outcome ; United States
Descrição: Altres ajuts: Janssen Biotech, Merck, Pharmacyclics, Incyte, Taiho Pharmaceutical. PURPOSE To assess the effect of clinical and pathological variables on cancer-specific and overall survival (OS) in de novo metastatic patients from a collaborative of primarily Latin American countries. PATIENTS AND METHODS Of 4,060 patients with renal cell carcinoma diagnosed between 1990 and 2015, a total of 530 (14.5%) had metastasis at clinical presentation. Relationships between clinical and pathological parameters and treatment-related outcomes were analyzed by Cox regression and the log-rank method. RESULTS Of 530 patients, 184 (90.6%) had died of renal cell carcinoma. The median OS of the entire cohort was 24 months. American Society of Anesthesiology classification 3-4 (hazard ratio [HR]: 1.64), perirenal fat invasion (HR: 2.02), and ≥ 2 metastatic organ sites (HR: 2.19) were independent prognostic factors for 5-year OS in multivariable analyses. We created a risk group stratification with these variables: no adverse risk factors (favorable group), median OS not reached; one adverse factor (intermediate group), median OS 33 months (HR: 2.04); and two or three adverse factors (poor risk group), median OS 14 months (HR: 3.58). CONCLUSION Our study defines novel prognostic factors that are relevant to a Latin American cohort. With external validation, these easily discerned clinical variables can be used to offer prognostic information across low- and middle-income countries.
Data de criação/publicação: 2021
Idioma: Inglês

Links

View record in Consorci de Serveis Universitaris de Catalunya (CSUC)$$FView record in $$GConsorci de Serveis Universitaris de Catalunya (CSUC)

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Prognostic factors in de novo metastatic renal cell carcinoma : A report from the latin american renal cancer group

2021

Buscando em bases de dados remotas. Favor aguardar.