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Population genetics and signatures of selection in Early Neolithic European farmers

Childebayeva, Ainash ; Rohrlach, Adam Benjamin ; Barquera, Rodrigo ; Rivollat, Maïté ; Aron, Franziska ; Szolek, Andras ; Kohlbacher, Oliver ; Nicklisch, Nicole ; Alt, Kurt W ; Gronenborn, Detlef ; Meller, Harald ; Friederich, Susanne ; Prufer, Kay ; Deguilloux, Marie-France ; Krause, Johannes ; Haak, Wolfgang

2022

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Título:
Population genetics and signatures of selection in Early Neolithic European farmers
Autor: Childebayeva, Ainash ; Rohrlach, Adam Benjamin ; Barquera, Rodrigo ; Rivollat, Maïté ; Aron, Franziska ; Szolek, Andras ; Kohlbacher, Oliver ; Nicklisch, Nicole ; Alt, Kurt W ; Gronenborn, Detlef ; Meller, Harald ; Friederich, Susanne ; Prufer, Kay ; Deguilloux, Marie-France ; Krause, Johannes ; Haak, Wolfgang
Assuntos: AGE ; ancient DNA ; ANKYLOSING-SPONDYLITIS ; ANTIGEN ; BEHCETS-DISEASE ; COLOR ; DNA-BASED EYE ; GENOME-WIDE ASSOCIATION ; History and Archaeology ; Linear Pottery culture ; neolithization ; PATTERNS ; PREDICTION ; selection ; SORBS1 GENE ; SUSCEPTIBILITY
Notas: MOLECULAR BIOLOGY AND EVOLUTION
ISSN: 0737-4038
ISSN: 1537-1719
Descrição: Human expansion in the course of the Neolithic transition in western Eurasia has been one of the major topics in ancient DNA research in the last 10 years. Multiple studies have shown that the spread of agriculture and animal husbandry from the Near East across Europe was accompanied by large-scale human expansions. Moreover, changes in subsistence and migration associated with the Neolithic transition have been hypothesized to involve genetic adaptation. Here, we present high quality genome-wide data from the Linear Pottery Culture site Derenburg-Meerenstieg II (DER) (N = 32 individuals) in Central Germany. Population genetic analyses show that the DER individuals carried predominantly Anatolian Neolithic-like ancestry and a very limited degree of local hunter-gatherer admixture, similar to other early European farmers. Increasing the Linear Pottery culture cohort size to similar to 100 individuals allowed us to perform various frequency- and haplotype-based analyses to investigate signatures of selection associated with changes following the adoption of the Neolithic lifestyle. In addition, we developed a new method called Admixture-informed Maximum-likelihood Estimation for Selection Scans that allowed us test for selection signatures in an admixture-aware fashion. Focusing on the intersection of results from these selection scans, we identified various loci associated with immune function (JAK1, HLA-DQB1) and metabolism (LMF1, LEPR, SORBS1), as well as skin color (SLC24A5, CD82) and folate synthesis (MTHFR, NBPF3). Our findings shed light on the evolutionary pressures, such as infectious disease and changing diet, that were faced by the early farmers of Western Eurasia.
Data de criação/publicação: 2022
Idioma: Inglês

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Population genetics and signatures of selection in Early Neolithic European farmers

2022

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