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Tumor-Treating Fields: A Fourth Modality in Cancer Treatment

Mun, Elijah J ; Babiker, Hani M ; Weinberg, Uri ; Kirson, Eilon D ; Von Hoff, Daniel D

Clinical cancer research, 2018-01, Vol.24 (2), p.266-275 [Periódico revisado por pares]

United States: American Association for Cancer Research Inc

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Título:
Tumor-Treating Fields: A Fourth Modality in Cancer Treatment
Autor: Mun, Elijah J ; Babiker, Hani M ; Weinberg, Uri ; Kirson, Eilon D ; Von Hoff, Daniel D
Assuntos: Animals ; Antitumor activity ; Apoptosis ; Cancer ; Cell cycle ; Clinical trials ; Clinical Trials as Topic ; Combined Modality Therapy - adverse effects ; Combined Modality Therapy - instrumentation ; Combined Modality Therapy - methods ; Electric fields ; Glioblastoma ; Glioblastoma multiforme ; Humans ; Immune response ; Immune system ; Medical research ; Mitosis ; Neoplasms - mortality ; Neoplasms - pathology ; Neoplasms - therapy ; Proteins ; Solid tumors ; Toxicity ; Treatment Outcome ; Tumors
É parte de: Clinical cancer research, 2018-01, Vol.24 (2), p.266-275
Descrição: Despite major advances in therapy, cancer continues to be a leading cause of mortality. In addition, toxicities of traditional therapies pose a significant challenge to tolerability and adherence. TTFields, a noninvasive anticancer treatment modality, utilizes alternating electric fields at specific frequencies and intensities to selectively disrupt mitosis in cancerous cells. TTFields target proteins crucial to the cell cycle, leading to mitotic arrest and apoptosis. TTFields also facilitate an antitumor immune response. Clinical trials of TTFields have proven safe and efficacious in patients with glioblastoma multiforme (GBM), and are FDA approved for use in newly diagnosed and recurrent GBM. Trials in other localized solid tumors are ongoing. .
Editor: United States: American Association for Cancer Research Inc
Idioma: Inglês

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Tumor-Treating Fields: A Fourth Modality in Cancer Treatment

Mun, Elijah J ; Babiker, Hani M ; Weinberg, Uri ; Kirson, Eilon D ; Von Hoff, Daniel D

United States: American Association for Cancer Research Inc

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