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Innate immunity and HPV: friends or foes

Nunes, Rafaella Almeida Lima; Morale, Mirian Galliote; Silva, Gabriela Ávila Fernandes; Villa, Luisa Lina; Termini, Lara

Clinics; v. 73 n. Suppl. 1 (2018); e549s

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo 2019-02-15

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  • Título:
    Innate immunity and HPV: friends or foes
  • Autor: Nunes, Rafaella Almeida Lima; Morale, Mirian Galliote; Silva, Gabriela Ávila Fernandes; Villa, Luisa Lina; Termini, Lara
  • Assuntos: Innate Immune System; Human Papillomavirus; Cervical Cancer
  • É parte de: Clinics; v. 73 n. Suppl. 1 (2018); e549s
  • Descrição: Most human papillomavirus infections are readily cleared by the host immune response. However, in some individuals, human papillomavirus can establish a persistent infection. The persistence of high-risk human papillomavirus infection is the major risk factor for cervical cancer development. These viruses have developed mechanisms to evade the host immune system, which is an important step in persistence and, ultimately, in tumor development. Several cell types, receptors, transcription factors and inflammatory mediators involved in the antiviral immune response are viral targets and contribute to tumorigenesis. These targets include antigen-presenting cells, macrophages, natural killer cells, Toll-like receptors, nuclear factor kappa B and several cytokines and chemokines, such as interleukins, interferon and tumor necrosis factor. In the present review, we address both the main innate immune response mechanisms involved in HPV infection clearance and the viral strategies that promote viral persistence and may contribute to cancer development. Finally, we discuss the possibility of exploiting this knowledge to develop effective therapeutic strategies.
  • Títulos relacionados: https://www.revistas.usp.br/clinics/article/view/154815/150799
  • Editor: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
  • Data de criação/publicação: 2019-02-15
  • Formato: Adobe PDF
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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