skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Paracoccidioidomycosis: Current Status and Future Trends

Hahn, Rosane Christine ; Hagen, Ferry ; Mendes, Rinaldo Poncio ; Burger, Eva ; Nery, Andreia Ferreira ; Siqueira, Nathan Pereira ; Guevara, Armando ; Rodrigues, Anderson Messias ; de Camargo, Zoilo Pires

Clinical microbiology reviews, 2022-12, Vol.35 (4), p.e0023321-e0023321 [Periódico revisado por pares]

United States: American Society for Microbiology

Texto completo disponível

Citações Citado por
  • Título:
    Paracoccidioidomycosis: Current Status and Future Trends
  • Autor: Hahn, Rosane Christine ; Hagen, Ferry ; Mendes, Rinaldo Poncio ; Burger, Eva ; Nery, Andreia Ferreira ; Siqueira, Nathan Pereira ; Guevara, Armando ; Rodrigues, Anderson Messias ; de Camargo, Zoilo Pires
  • Assuntos: Brazil ; Humans ; Mycology ; Paracoccidioides ; Paracoccidioidomycosis - diagnosis ; Paracoccidioidomycosis - drug therapy ; Paracoccidioidomycosis - epidemiology ; Review ; Skin
  • É parte de: Clinical microbiology reviews, 2022-12, Vol.35 (4), p.e0023321-e0023321
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    The authors declare no conflict of interest.
  • Descrição: Paracoccidioidomycosis (PCM), initially reported in 1908 in the city of São Paulo, Brazil, by Adolpho Lutz, is primarily a systemic and neglected tropical mycosis that may affect individuals with certain risk factors around Latin America, especially Brazil. Paracoccidioides brasiliensis , a classical thermodimorphic fungus associated with PCM, was long considered to represent a monotypic taxon. However, advances in molecular taxonomy revealed several cryptic species, including Paracoccidioides americana, P. restrepiensis, P. venezuelensis, and P. lutzii, that show a preference for skin and mucous membranes, lymph nodes, and respiratory organs but can also affect many other organs. The classical diagnosis of PCM benefits from direct microscopy culture-based, biochemical, and immunological assays in a general microbiology laboratory practice providing a generic identification of the agents. However, molecular assays should be employed to identify isolates to the species level, data that would be complemented by epidemiological investigations. From a clinical perspective, all probable and confirmed cases should be treated. The choice of treatment and its duration must be considered, along with the affected organs, process severity, history of previous treatment failure, possibility of administering oral medication, associated diseases, pregnancy, and patient compliance with the proposed treatment regimen. Nevertheless, even after appropriate treatment, there may be relapses, which generally occur 5 years after the apparent cure following treatment, and also, the mycosis may be confused with other diseases. This review provides a comprehensive and critical overview of the immunopathology, laboratory diagnosis, clinical aspects, and current treatment of PCM, highlighting current issues in the identification, treatment, and patient follow-up in light of recent species taxonomic developments.
  • Editor: United States: American Society for Microbiology
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.