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Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo

Ribeiro, Joana ; Araújo-Silva, Henrique ; Fernandes, Mário ; da Silva, Joilna Alves ; Pinto, Francisco das Chagas L. ; Pessoa, Otília Deusdenia L. ; Santos, Hélcio Silva ; de Menezes, Jane Eire Silva Alencar ; Gomes, Andreia C.

Natural Products and Bioprospecting, 2024-12, Vol.14 (1), p.16-16 [Periódico revisado por pares]

Singapore: Springer Nature Singapore

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Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
Autor: Ribeiro, Joana ; Araújo-Silva, Henrique ; Fernandes, Mário ; da Silva, Joilna Alves ; Pinto, Francisco das Chagas L. ; Pessoa, Otília Deusdenia L. ; Santos, Hélcio Silva ; de Menezes, Jane Eire Silva Alencar ; Gomes, Andreia C.
Assuntos: Acetylcholine ; Acetylcholinesterase ; Advertising executives ; Aluminium-induced neurotoxicity ; Aluminum ; Aluminum chloride ; Alzheimer's disease ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Danio rerio ; Development and progression ; Disease ; Embryonic development ; Embryos ; Ethylenediaminetetraacetic acid ; Food Science ; Life Sciences ; Marine organisms ; Medical research ; Medicinal Chemistry ; Medicine, Experimental ; Nervous system diseases ; Neurodegenerative diseases ; Neuroprotection ; Neurotoxicity ; Original ; Original Article ; Petrosamine ; Petrosia sp ; Pharmacology/Toxicology ; Plant Biochemistry ; Plant Sciences ; Protection and preservation ; Zebrafish
É parte de: Natural Products and Bioprospecting, 2024-12, Vol.14 (1), p.16-16
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer from Alzheimer’s Disease (AD). A crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (AChE) activity. Marine organisms synthesize several classes of compounds, some of which exhibit significant AChE inhibition, such as petrosamine, a coloured pyridoacridine alkaloid. The aim of this work was to characterize the activity of petrosamine isolated for the first time from a Brazilian marine sponge, using two neurotoxicity models with aluminium chloride, as exposure to aluminium is associated with the development of neurodegenerative diseases. The in vitro model was based in a neuroblastoma cell line and the in vivo model exploited the potential of zebrafish ( Danio rerio ) embryos in mimicking hallmarks of AD. To our knowledge, this is the first report on petrosamine’s activity over these parameters, either in vitro or in vivo, in order to characterize its full potential for tackling neurotoxicity. Graphical Abstract
Editor: Singapore: Springer Nature Singapore
Idioma: Inglês

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Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo

Ribeiro, Joana ; Araújo-Silva, Henrique ; Fernandes, Mário ; da Silva, Joilna Alves ; Pinto, Francisco das Chagas L. ; Pessoa, Otília Deusdenia L. ; Santos, Hélcio Silva ; de Menezes, Jane Eire Silva Alencar ; Gomes, Andreia C.

Singapore: Springer Nature Singapore

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